3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
The object of the present invention is to provide a compound having an antagonistic action against µ-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof: wherein R 1 and R 2 are th...
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| creator | SHIMIZU, MOTOHISA SETOGUCHI, HIROYUKI IZUCHI, TORU TSUZAKI, YASUNORI IWAMURA, RYO KURUMAZUKA, DAISUKE KIMURA, TOMIO AKAZA, HIROTO TANIKO, KAORI MIYAZAWA, TOSHIYUKI OKABE, MORIO HARADA, SATOKO IMURA, YUUKI KANEKO, TATSUROH |
| description | The object of the present invention is to provide a compound having an antagonistic action against µ-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof:
wherein
R 1 and R 2 are the same or different, and each represents a hydrogen atom or a halogen atom, provided that R 1 and R 2 are not simultaneously halogen atoms,
R 3 represents a C 1 -C 3 alkyl group or a vinyl group, and
R 4 represents the formula (II):
wherein R 5 represents a hydroxy group or a C 1 -C 3 alkoxy group, and R 6 and R 7 are the same or different, and each represents a hydrogen atom or a halogen atom;
or the formula (III):
wherein Ring A represents a halogen atom(s)-substituted C 5 -C 7 cycloalkyl group which is optionally substituted by a C 1 -C 3 alkoxy group, or a halogen atom(s)-substituted 5- to 7-membered saturated heterocyclic group. |
| format | Patent |
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wherein
R 1 and R 2 are the same or different, and each represents a hydrogen atom or a halogen atom, provided that R 1 and R 2 are not simultaneously halogen atoms,
R 3 represents a C 1 -C 3 alkyl group or a vinyl group, and
R 4 represents the formula (II):
wherein R 5 represents a hydroxy group or a C 1 -C 3 alkoxy group, and R 6 and R 7 are the same or different, and each represents a hydrogen atom or a halogen atom;
or the formula (III):
wherein Ring A represents a halogen atom(s)-substituted C 5 -C 7 cycloalkyl group which is optionally substituted by a C 1 -C 3 alkoxy group, or a halogen atom(s)-substituted 5- to 7-membered saturated heterocyclic group.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160928&DB=EPODOC&CC=EP&NR=3072884A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160928&DB=EPODOC&CC=EP&NR=3072884A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHIMIZU, MOTOHISA</creatorcontrib><creatorcontrib>SETOGUCHI, HIROYUKI</creatorcontrib><creatorcontrib>IZUCHI, TORU</creatorcontrib><creatorcontrib>TSUZAKI, YASUNORI</creatorcontrib><creatorcontrib>IWAMURA, RYO</creatorcontrib><creatorcontrib>KURUMAZUKA, DAISUKE</creatorcontrib><creatorcontrib>KIMURA, TOMIO</creatorcontrib><creatorcontrib>AKAZA, HIROTO</creatorcontrib><creatorcontrib>TANIKO, KAORI</creatorcontrib><creatorcontrib>MIYAZAWA, TOSHIYUKI</creatorcontrib><creatorcontrib>OKABE, MORIO</creatorcontrib><creatorcontrib>HARADA, SATOKO</creatorcontrib><creatorcontrib>IMURA, YUUKI</creatorcontrib><creatorcontrib>KANEKO, TATSUROH</creatorcontrib><title>3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES</title><description>The object of the present invention is to provide a compound having an antagonistic action against µ-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof:
wherein
R 1 and R 2 are the same or different, and each represents a hydrogen atom or a halogen atom, provided that R 1 and R 2 are not simultaneously halogen atoms,
R 3 represents a C 1 -C 3 alkyl group or a vinyl group, and
R 4 represents the formula (II):
wherein R 5 represents a hydroxy group or a C 1 -C 3 alkoxy group, and R 6 and R 7 are the same or different, and each represents a hydrogen atom or a halogen atom;
or the formula (III):
wherein Ring A represents a halogen atom(s)-substituted C 5 -C 7 cycloalkyl group which is optionally substituted by a C 1 -C 3 alkoxy group, or a halogen atom(s)-substituted 5- to 7-membered saturated heterocyclic group.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPA01nWMcnTydI509vGPNtYz1DOI9XCNcPRzVXBxDfIMcwzxDHNVcPRzUQgNdlUI8XANcvV3U3DzD1LwdXXxdHb0UQgIDQrwD3YN5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BxgbmRhYWJo6GxkQoAQCrcixx</recordid><startdate>20160928</startdate><enddate>20160928</enddate><creator>SHIMIZU, MOTOHISA</creator><creator>SETOGUCHI, HIROYUKI</creator><creator>IZUCHI, TORU</creator><creator>TSUZAKI, YASUNORI</creator><creator>IWAMURA, RYO</creator><creator>KURUMAZUKA, DAISUKE</creator><creator>KIMURA, TOMIO</creator><creator>AKAZA, HIROTO</creator><creator>TANIKO, KAORI</creator><creator>MIYAZAWA, TOSHIYUKI</creator><creator>OKABE, MORIO</creator><creator>HARADA, SATOKO</creator><creator>IMURA, YUUKI</creator><creator>KANEKO, TATSUROH</creator><scope>EVB</scope></search><sort><creationdate>20160928</creationdate><title>3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES</title><author>SHIMIZU, MOTOHISA ; SETOGUCHI, HIROYUKI ; IZUCHI, TORU ; TSUZAKI, YASUNORI ; IWAMURA, RYO ; KURUMAZUKA, DAISUKE ; KIMURA, TOMIO ; AKAZA, HIROTO ; TANIKO, KAORI ; MIYAZAWA, TOSHIYUKI ; OKABE, MORIO ; HARADA, SATOKO ; IMURA, YUUKI ; KANEKO, TATSUROH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3072884A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIMIZU, MOTOHISA</creatorcontrib><creatorcontrib>SETOGUCHI, HIROYUKI</creatorcontrib><creatorcontrib>IZUCHI, TORU</creatorcontrib><creatorcontrib>TSUZAKI, YASUNORI</creatorcontrib><creatorcontrib>IWAMURA, RYO</creatorcontrib><creatorcontrib>KURUMAZUKA, DAISUKE</creatorcontrib><creatorcontrib>KIMURA, TOMIO</creatorcontrib><creatorcontrib>AKAZA, HIROTO</creatorcontrib><creatorcontrib>TANIKO, KAORI</creatorcontrib><creatorcontrib>MIYAZAWA, TOSHIYUKI</creatorcontrib><creatorcontrib>OKABE, MORIO</creatorcontrib><creatorcontrib>HARADA, SATOKO</creatorcontrib><creatorcontrib>IMURA, YUUKI</creatorcontrib><creatorcontrib>KANEKO, TATSUROH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHIMIZU, MOTOHISA</au><au>SETOGUCHI, HIROYUKI</au><au>IZUCHI, TORU</au><au>TSUZAKI, YASUNORI</au><au>IWAMURA, RYO</au><au>KURUMAZUKA, DAISUKE</au><au>KIMURA, TOMIO</au><au>AKAZA, HIROTO</au><au>TANIKO, KAORI</au><au>MIYAZAWA, TOSHIYUKI</au><au>OKABE, MORIO</au><au>HARADA, SATOKO</au><au>IMURA, YUUKI</au><au>KANEKO, TATSUROH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES</title><date>2016-09-28</date><risdate>2016</risdate><abstract>The object of the present invention is to provide a compound having an antagonistic action against µ-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof:
wherein
R 1 and R 2 are the same or different, and each represents a hydrogen atom or a halogen atom, provided that R 1 and R 2 are not simultaneously halogen atoms,
R 3 represents a C 1 -C 3 alkyl group or a vinyl group, and
R 4 represents the formula (II):
wherein R 5 represents a hydroxy group or a C 1 -C 3 alkoxy group, and R 6 and R 7 are the same or different, and each represents a hydrogen atom or a halogen atom;
or the formula (III):
wherein Ring A represents a halogen atom(s)-substituted C 5 -C 7 cycloalkyl group which is optionally substituted by a C 1 -C 3 alkoxy group, or a halogen atom(s)-substituted 5- to 7-membered saturated heterocyclic group.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES |
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