AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivativ...

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Bibliographische Detailangaben

Hauptverfasser:	DAILEY, Ian, DAVIS, Stephen, BURKE, Martin D, STRUBLE, Justin, GRAY, Kaitlyn C, PALYAM, Nagarjuna, WANG, Pulin, UNO, Brice E, KNAPP, David M
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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