PROCESS FOR THE PREPARATION OF ESTETROL

PROCESS FOR THE PREPARATION OF ESTETROL

The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a salt or solvate thereof, wherein R1 is a hydroxyl protecting group selected from a silyl ether, an ether, an ester, a carbamate and a carbonate,...

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Hauptverfasser: FERREIRO GIL, Juan José, GALLO NIETO, Francisco Javier, IGLESIAS RETUERTO, Jesús Miguel
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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creator FERREIRO GIL, Juan José
GALLO NIETO, Francisco Javier
IGLESIAS RETUERTO, Jesús Miguel
description The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a salt or solvate thereof, wherein R1 is a hydroxyl protecting group selected from a silyl ether, an ether, an ester, a carbamate and a carbonate, and R2 is a hydroxyl protecting group selected from an ether, with an oxidizing agent selected from OsO4 or a source of osmium tetroxide to produce Estetrol or a compound of formula (II) or a salt or solvate thereof wherein R1 is as defined previously; and b) if a compound of formula (II) is obtained in step a), deprotecting said compound to produce Estetrol.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
title PROCESS FOR THE PREPARATION OF ESTETROL
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