METHOD FOR TRANSFERRING PRECISE SMALL VOLUMES OF LIQUIDS

In a method for transferring precise small volumes of liquids (54, 64), the pressure in a defined volume portion (14) of a fluid passageway (12) is measured by means of two pressure sensors in fluid communication with the defined volume portion. A liquid (54, 64) is then added to the defined volume...

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Bibliographische Detailangaben
Hauptverfasser:	Lambert, Joseph J, Herman, David L
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BLASTING CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY CONTROLLING HEATING LIGHTING MEASURING MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUIDLEVEL MECHANICAL ENGINEERING METALLURGY METERING BY VOLUME ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BYUSING INERTIA OF FLUID TO BE PUMPED PUMPS FOR LIQUIDS OR ELASTIC FLUIDS REGULATING SIPHONS SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES TESTING THEIR RELEVANT APPARATUS TRANSPORTING WEAPONS
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Beschreibung
Zusammenfassung:	In a method for transferring precise small volumes of liquids (54, 64), the pressure in a defined volume portion (14) of a fluid passageway (12) is measured by means of two pressure sensors in fluid communication with the defined volume portion. A liquid (54, 64) is then added to the defined volume portion of the fluid passageway until the measured pressure indicates that a predetermined volume of liquid has been transferred into the passageway. The measured volume of liquid can then be transferred from the fluid passageway to a reactor (13). The invention has particular utility for chemical reactions carried out using complex manipulations (e.g. combinatorial chemistry) or the synthesis of complex compositions such as peptides. Using solid phase peptide synthesis (SPPS).