PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS

Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositi...

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Bibliographische Detailangaben
Hauptverfasser:	CURTIN, Michael L, GONG, Jianchun, PENNING, Thomas, TAO, Zhi-fu, GOSWAMI, Rajeev, LAI, Chunqiu, WOODS, Keith W, FLORJANCIC, Alan S, MIYASHIRO, Juliem, DABBEERU, Madhu Babu, HANSEN, Todd M, SOUERS, Andrew, JI, Zhiqin, TONG, Yunsong, BRUNCKO, Milan, CLARK, Richard F, IQUTURI, Omprakash Reddy, MICHAELIDES, Michael, ZHU, Guidong, RISI, Roberto M, MASTRACCHIO, Anthony, SONG, Xiaohong, FREY, Robin R
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).