HSP70 BINDING COMPOUND, USE, ANTITUMOUR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR EXPRESSING AN HSP70 BINDER, PRODUCTION PROCESS, PROCESS FOR EVALUATING TUMOUR CELLS, METHOD OF SENSITIZATION OF TUMOUR CELLS TO CHEMOTHERAPEUTIC DRUGS

HSP70 BINDING COMPOUND, USE, ANTITUMOUR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR EXPRESSING AN HSP70 BINDER, PRODUCTION PROCESS, PROCESS FOR EVALUATING TUMOUR CELLS, METHOD OF SENSITIZATION OF TUMOUR CELLS TO CHEMOTHERAPEUTIC DRUGS

The present invention provides the use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. Also disclosed are: a gene construct for the expression of said protein; a production proce...

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Hauptverfasser: DUARTE DE SOUZA, ANA PAULA, CAZABUENA BONORINO, CRISTINA BEATRIZ
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator DUARTE DE SOUZA, ANA PAULA
CAZABUENA BONORINO, CRISTINA BEATRIZ
description The present invention provides the use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. Also disclosed are: a gene construct for the expression of said protein; a production process; a process of evaluation of tumor cells; and a method of sensitization of tumors to chemotherapeutic agents. The invention also provides a new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions of the invention provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells. These and other advantages of the invention are characterized as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HSP70 BINDING COMPOUND, USE, ANTITUMOUR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR EXPRESSING AN HSP70 BINDER, PRODUCTION PROCESS, PROCESS FOR EVALUATING TUMOUR CELLS, METHOD OF SENSITIZATION OF TUMOUR CELLS TO CHEMOTHERAPEUTIC DRUGS
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