FACTOR IXA INHIBITORS
The present invention provides a compound of Formula (I) wherein R1, R2, R3 and R4 are independently H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl, and when R2, R3, and R4 a...
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| creator | ZHANG, Ting GUO, Liangqin CHEN, Yi-Heng CHACKALAMANNIL, Samuel BALKOVEC, James GREENLEE, William, John HIRABAYASHI, Tomokazu KATSUNO, Mika TAN, John, Qiang SMITH, Cameron, James CHEN, Yili |
| description | The present invention provides a compound of Formula (I) wherein R1, R2, R3 and R4 are independently H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl, and when R2, R3, and R4 are H, R is C1-6 alkyl; and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. |
| format | Patent |
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KATSUNO, Mika ; TAN, John, Qiang ; SMITH, Cameron, James ; CHEN, Yili</creatorcontrib><description>The present invention provides a compound of Formula (I) wherein R1, R2, R3 and R4 are independently H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl, and when R2, R3, and R4 are H, R is C1-6 alkyl; and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180404&DB=EPODOC&CC=EP&NR=2934537B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180404&DB=EPODOC&CC=EP&NR=2934537B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG, Ting</creatorcontrib><creatorcontrib>GUO, Liangqin</creatorcontrib><creatorcontrib>CHEN, Yi-Heng</creatorcontrib><creatorcontrib>CHACKALAMANNIL, Samuel</creatorcontrib><creatorcontrib>BALKOVEC, James</creatorcontrib><creatorcontrib>GREENLEE, William, John</creatorcontrib><creatorcontrib>HIRABAYASHI, Tomokazu</creatorcontrib><creatorcontrib>KATSUNO, Mika</creatorcontrib><creatorcontrib>TAN, John, Qiang</creatorcontrib><creatorcontrib>SMITH, Cameron, James</creatorcontrib><creatorcontrib>CHEN, Yili</creatorcontrib><title>FACTOR IXA INHIBITORS</title><description>The present invention provides a compound of Formula (I) wherein R1, R2, R3 and R4 are independently H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl, and when R2, R3, and R4 are H, R is C1-6 alkyl; and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBB1c3QO8Q9S8IxwVPD08_B08gTygnkYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgJGlsYmpsbmToTERSgBaxB6E</recordid><startdate>20180404</startdate><enddate>20180404</enddate><creator>ZHANG, Ting</creator><creator>GUO, Liangqin</creator><creator>CHEN, Yi-Heng</creator><creator>CHACKALAMANNIL, Samuel</creator><creator>BALKOVEC, James</creator><creator>GREENLEE, William, John</creator><creator>HIRABAYASHI, Tomokazu</creator><creator>KATSUNO, Mika</creator><creator>TAN, John, Qiang</creator><creator>SMITH, Cameron, James</creator><creator>CHEN, Yili</creator><scope>EVB</scope></search><sort><creationdate>20180404</creationdate><title>FACTOR IXA INHIBITORS</title><author>ZHANG, Ting ; GUO, Liangqin ; CHEN, Yi-Heng ; CHACKALAMANNIL, Samuel ; BALKOVEC, James ; GREENLEE, William, John ; HIRABAYASHI, Tomokazu ; KATSUNO, Mika ; TAN, John, Qiang ; SMITH, Cameron, James ; CHEN, Yili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2934537B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG, Ting</creatorcontrib><creatorcontrib>GUO, Liangqin</creatorcontrib><creatorcontrib>CHEN, Yi-Heng</creatorcontrib><creatorcontrib>CHACKALAMANNIL, Samuel</creatorcontrib><creatorcontrib>BALKOVEC, James</creatorcontrib><creatorcontrib>GREENLEE, William, John</creatorcontrib><creatorcontrib>HIRABAYASHI, Tomokazu</creatorcontrib><creatorcontrib>KATSUNO, Mika</creatorcontrib><creatorcontrib>TAN, John, Qiang</creatorcontrib><creatorcontrib>SMITH, Cameron, James</creatorcontrib><creatorcontrib>CHEN, Yili</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG, Ting</au><au>GUO, Liangqin</au><au>CHEN, Yi-Heng</au><au>CHACKALAMANNIL, Samuel</au><au>BALKOVEC, James</au><au>GREENLEE, William, John</au><au>HIRABAYASHI, Tomokazu</au><au>KATSUNO, Mika</au><au>TAN, John, Qiang</au><au>SMITH, Cameron, James</au><au>CHEN, Yili</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FACTOR IXA INHIBITORS</title><date>2018-04-04</date><risdate>2018</risdate><abstract>The present invention provides a compound of Formula (I) wherein R1, R2, R3 and R4 are independently H or C1-6 alkyl, provided that when R1, R2, and R3 are H, R4 is C1-6 alkyl, and when R1, R2, and R4 are H, R3 is C1-6 alkyl, and when R1, R3, and R4 are H, R2 is C1-6 alkyl, and when R2, R3, and R4 are H, R is C1-6 alkyl; and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | FACTOR IXA INHIBITORS |
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