BRUTON'S TYROSINE KINASE INHIBITORS
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in comb...
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| creator | ZAPF, Christoph Wolfgang XING, Li SELNESS, Shaun Raj SCHNUTE, Mark Edward GARLAND, Danny James HUGHES, Robert Owen WALKER, Daniel Patrick SCHMIDT, Michelle, Ann DEVADAS, Balekudru HAN, Seungil WAN, Zhao-Kui GRAPPERHAUS, Margaret Lanahan SPRINGER, John Robert HOCKERMAN, Susan Landis SAIAH, Eddine |
| description | Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. |
| format | Patent |
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Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170405&DB=EPODOC&CC=EP&NR=2914586B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170405&DB=EPODOC&CC=EP&NR=2914586B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZAPF, Christoph Wolfgang</creatorcontrib><creatorcontrib>XING, Li</creatorcontrib><creatorcontrib>SELNESS, Shaun Raj</creatorcontrib><creatorcontrib>SCHNUTE, Mark Edward</creatorcontrib><creatorcontrib>GARLAND, Danny James</creatorcontrib><creatorcontrib>HUGHES, Robert Owen</creatorcontrib><creatorcontrib>WALKER, Daniel Patrick</creatorcontrib><creatorcontrib>SCHMIDT, Michelle, Ann</creatorcontrib><creatorcontrib>DEVADAS, Balekudru</creatorcontrib><creatorcontrib>HAN, Seungil</creatorcontrib><creatorcontrib>WAN, Zhao-Kui</creatorcontrib><creatorcontrib>GRAPPERHAUS, Margaret Lanahan</creatorcontrib><creatorcontrib>SPRINGER, John Robert</creatorcontrib><creatorcontrib>HOCKERMAN, Susan Landis</creatorcontrib><creatorcontrib>SAIAH, Eddine</creatorcontrib><title>BRUTON'S TYROSINE KINASE INHIBITORS</title><description>Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). 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Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BRUTON'S TYROSINE KINASE INHIBITORS |
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