THE DETECTION OF FREE AND PROTEIN-BOUND NON-HUMAN GAL-ALPHA-(1-3)-GAL EPITOPE

THE DETECTION OF FREE AND PROTEIN-BOUND NON-HUMAN GAL-ALPHA-(1-3)-GAL EPITOPE

The present invention relates to the provision of antibody fragments capable of binding selectively to the Gal-±-(1†’3)-Gal epitope. The invention further relates to assay systems comprising these antibody fragments for use in testing transplantation tissue for possible rejection complications. This...

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Hauptverfasser: GLAVIN, John, CUNNINGHAM, Stephen, JOSHI, Lokesh, STARR, Emily, KANE, Marian, SHAW, Iain
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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creator GLAVIN, John
CUNNINGHAM, Stephen
JOSHI, Lokesh
STARR, Emily
KANE, Marian
SHAW, Iain
description The present invention relates to the provision of antibody fragments capable of binding selectively to the Gal-±-(1†’3)-Gal epitope. The invention further relates to assay systems comprising these antibody fragments for use in testing transplantation tissue for possible rejection complications. This epitope is often found on porcine tissue destined for human transplantation. The epitope is also found on biopharmaceuticals and on some infectious agents and accordingly the invention also provides assay systems for these applications.
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subjects CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
title THE DETECTION OF FREE AND PROTEIN-BOUND NON-HUMAN GAL-ALPHA-(1-3)-GAL EPITOPE
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