ENZYME HYALURONAN-LYASE, METHOD OF PRODUCTION THEREOF, USE THEREOF AND METHOD OF PREPARATION OF LOW-MOLECULAR HYALURONAN

ENZYME HYALURONAN-LYASE, METHOD OF PRODUCTION THEREOF, USE THEREOF AND METHOD OF PREPARATION OF LOW-MOLECULAR HYALURONAN

The invention relates to an enzyme which is able to degrade hyaluronic acid and which is produced by fungi of the genus Fistulina (especially Fistulina hepatica). The degradation proceeds by lyase mechanism in which double bonds between C4 and C5 of glucuronic acid are formed. The invention also inc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KNOROVA, LENKA, VELEBNY, VLADIMIR, SMIRNOU, DZIANIS, KRCMAR, MARTIN, LEIEROVA, VERONIKA, FRANKE, LUKAS
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention relates to an enzyme which is able to degrade hyaluronic acid and which is produced by fungi of the genus Fistulina (especially Fistulina hepatica). The degradation proceeds by lyase mechanism in which double bonds between C4 and C5 of glucuronic acid are formed. The invention also includes the process of preparation and purification of the enzyme and a possible practical use thereof for the preparation of low-molecular hyaluronan or of cosmetic or pharmaceutical devices. Further, the invention relates to the method of preparation of low-molecular hyaluronan.