PYRAZOLYL-UREAS AS KINASE INHIBITORS
There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and membe...
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| creator | FYFE, MATTHEW, COLIN, THOR ONIONS, STUART, THOMAS HAMZA, DANIEL KING-UNDERWOOD, JOHN CARIOU, CLAIRE, ANNE, MARIE ITO, KAZUHIRO MURRAY, PETER, JOHN WILLIAMS, JONATHAN, GARETH FORDYCE, EUAN, ALEXANDER, FRASER THOM, STEPHEN, MALCOLM WATSON, HAYLEY, TEGAN, ANGELA CHARRON, CATHERINE, ELISABETH |
| description | There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines. |
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ONIONS, STUART, THOMAS ; HAMZA, DANIEL ; KING-UNDERWOOD, JOHN ; CARIOU, CLAIRE, ANNE, MARIE ; ITO, KAZUHIRO ; MURRAY, PETER, JOHN ; WILLIAMS, JONATHAN, GARETH ; FORDYCE, EUAN, ALEXANDER, FRASER ; THOM, STEPHEN, MALCOLM ; WATSON, HAYLEY, TEGAN, ANGELA ; CHARRON, CATHERINE, ELISABETH</creatorcontrib><description>There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; 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ONIONS, STUART, THOMAS ; HAMZA, DANIEL ; KING-UNDERWOOD, JOHN ; CARIOU, CLAIRE, ANNE, MARIE ; ITO, KAZUHIRO ; MURRAY, PETER, JOHN ; WILLIAMS, JONATHAN, GARETH ; FORDYCE, EUAN, ALEXANDER, FRASER ; THOM, STEPHEN, MALCOLM ; WATSON, HAYLEY, TEGAN, ANGELA ; CHARRON, CATHERINE, ELISABETH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2885284A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FYFE, MATTHEW, COLIN, THOR</creatorcontrib><creatorcontrib>ONIONS, STUART, THOMAS</creatorcontrib><creatorcontrib>HAMZA, DANIEL</creatorcontrib><creatorcontrib>KING-UNDERWOOD, JOHN</creatorcontrib><creatorcontrib>CARIOU, CLAIRE, ANNE, MARIE</creatorcontrib><creatorcontrib>ITO, KAZUHIRO</creatorcontrib><creatorcontrib>MURRAY, PETER, JOHN</creatorcontrib><creatorcontrib>WILLIAMS, JONATHAN, GARETH</creatorcontrib><creatorcontrib>FORDYCE, EUAN, ALEXANDER, FRASER</creatorcontrib><creatorcontrib>THOM, STEPHEN, MALCOLM</creatorcontrib><creatorcontrib>WATSON, HAYLEY, TEGAN, ANGELA</creatorcontrib><creatorcontrib>CHARRON, CATHERINE, ELISABETH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FYFE, MATTHEW, COLIN, THOR</au><au>ONIONS, STUART, THOMAS</au><au>HAMZA, DANIEL</au><au>KING-UNDERWOOD, JOHN</au><au>CARIOU, CLAIRE, ANNE, MARIE</au><au>ITO, KAZUHIRO</au><au>MURRAY, PETER, JOHN</au><au>WILLIAMS, JONATHAN, GARETH</au><au>FORDYCE, EUAN, ALEXANDER, FRASER</au><au>THOM, STEPHEN, MALCOLM</au><au>WATSON, HAYLEY, TEGAN, ANGELA</au><au>CHARRON, CATHERINE, ELISABETH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLYL-UREAS AS KINASE INHIBITORS</title><date>2015-06-24</date><risdate>2015</risdate><abstract>There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRAZOLYL-UREAS AS KINASE INHIBITORS |
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