PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS

PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when...

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Hauptverfasser: RONAN, Baptiste, MUZET, Nicolas, FILOCHE-ROMME, Bruno, MARCINIAK, Gilbert, EL-AHMAD, Youssef, VIVET, Bertrand, GANZHORM, Axel, ZERR, Véronique
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator RONAN, Baptiste
MUZET, Nicolas
FILOCHE-ROMME, Bruno
MARCINIAK, Gilbert
EL-AHMAD, Youssef
VIVET, Bertrand
GANZHORM, Axel
ZERR, Véronique
description The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS
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