PYRIMIDINO[1,2-C]QUINAZOLINONE DERIVATIVES AS TYROSINE KINASES INHIBITORS
The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal c...
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| creator | HULL, CLARENCE EUGENE, III MALONE, THOMAS C WURSTER, JULIE A |
| description | The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. |
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The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150401&DB=EPODOC&CC=EP&NR=2852594A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150401&DB=EPODOC&CC=EP&NR=2852594A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HULL, CLARENCE EUGENE, III</creatorcontrib><creatorcontrib>MALONE, THOMAS C</creatorcontrib><creatorcontrib>WURSTER, JULIE A</creatorcontrib><title>PYRIMIDINO[1,2-C]QUINAZOLINONE DERIVATIVES AS TYROSINE KINASES INHIBITORS</title><description>The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMiAzy9PV08fTzjzbUMdJ1jg0M9fRzjPL3AYr4uSq4uAZ5hjmGeIa5Bis4BiuERAb5B3sCxb2BioKBYp5-Hp5OniH-QcE8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeNcDIwtTI1NLE0dCYCCUAOXgthQ</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>HULL, CLARENCE EUGENE, III</creator><creator>MALONE, THOMAS C</creator><creator>WURSTER, JULIE A</creator><scope>EVB</scope></search><sort><creationdate>20150401</creationdate><title>PYRIMIDINO[1,2-C]QUINAZOLINONE DERIVATIVES AS TYROSINE KINASES INHIBITORS</title><author>HULL, CLARENCE EUGENE, III ; MALONE, THOMAS C ; WURSTER, JULIE A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2852594A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HULL, CLARENCE EUGENE, III</creatorcontrib><creatorcontrib>MALONE, THOMAS C</creatorcontrib><creatorcontrib>WURSTER, JULIE A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HULL, CLARENCE EUGENE, III</au><au>MALONE, THOMAS C</au><au>WURSTER, JULIE A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRIMIDINO[1,2-C]QUINAZOLINONE DERIVATIVES AS TYROSINE KINASES INHIBITORS</title><date>2015-04-01</date><risdate>2015</risdate><abstract>The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. 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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRIMIDINO[1,2-C]QUINAZOLINONE DERIVATIVES AS TYROSINE KINASES INHIBITORS |
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