Antagonists of the glucagon receptor
The present invention provides for novel compounds of Formula I and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as the...
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| creator | BOYER, Serge, Henri SUN, Zhili REDDY, Mali, Venkat CRAIGO, William LEMUS, Robert, Huerta NGUYEN, Thanh, Huu GOMEZ-GALENO, Jorge, E DANG, Qun HECKER, Scott, J REDDY, Raja, K VAN POLJE, Paul, D GROTE, Matthew, P LI, Haiqing CHEN, Mingwei |
| description | The present invention provides for novel compounds of Formula I and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as their use in methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia. |
| format | Patent |
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The present invention further provides for pharmaceutical compositions comprising the same as well as their use in methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia.</description><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181128&DB=EPODOC&CC=EP&NR=2786985B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181128&DB=EPODOC&CC=EP&NR=2786985B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOYER, Serge, Henri</creatorcontrib><creatorcontrib>SUN, Zhili</creatorcontrib><creatorcontrib>REDDY, Mali, Venkat</creatorcontrib><creatorcontrib>CRAIGO, William</creatorcontrib><creatorcontrib>LEMUS, Robert, Huerta</creatorcontrib><creatorcontrib>NGUYEN, Thanh, Huu</creatorcontrib><creatorcontrib>GOMEZ-GALENO, Jorge, E</creatorcontrib><creatorcontrib>DANG, Qun</creatorcontrib><creatorcontrib>HECKER, Scott, J</creatorcontrib><creatorcontrib>REDDY, Raja, K</creatorcontrib><creatorcontrib>VAN POLJE, Paul, D</creatorcontrib><creatorcontrib>GROTE, Matthew, P</creatorcontrib><creatorcontrib>LI, Haiqing</creatorcontrib><creatorcontrib>CHEN, Mingwei</creatorcontrib><title>Antagonists of the glucagon receptor</title><description>The present invention provides for novel compounds of Formula I and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. 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The present invention further provides for pharmaceutical compositions comprising the same as well as their use in methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Antagonists of the glucagon receptor |
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