Process for the preparation of hydroxytyrosol
Preparing hydroxytyrosol involves reacting substituted benzene diol derivative with an aluminum compound; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solven...
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| creator | FLEISCHMANN, GERALD KRÜGER, BENNO PETERSEN, HERMANN |
| description | Preparing hydroxytyrosol involves reacting substituted benzene diol derivative with an aluminum compound; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solvent; and removing the organic solvent. Preparing hydroxytyrosol involves reacting substituted benzene diol derivative of formula (I) with an aluminum compound of formula AlR 7R 8R 9; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solvent; and removing the organic solvent. X : CH 2OH or CH 2OM; M : Li, Na, K, Mg or Ca; R 1 and R 2 : 1-8C alkyl (optionally aryl substituted), benzyl (optionally alkyl or halogen substituted); R 1+R 2 : -C(R 3)(R 4)- or -CH(R 5)CH(R 6)-; R 3-R 6 : H or 1-6C alkyl, or aryl(optionally alkyl substituted);or R 5+R 6 : -(CH 2) 4-, -(CH 2) 5- or -(CH 2) 6-; R 7-R 9 : H or 1-8C alkyl. [Image] ACTIVITY : Antiinflammatory; Antimicrobial; Antibacterial; Neuroprotective; Apoptotic. |
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Preparing hydroxytyrosol involves reacting substituted benzene diol derivative of formula (I) with an aluminum compound of formula AlR 7R 8R 9; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solvent; and removing the organic solvent. X : CH 2OH or CH 2OM; M : Li, Na, K, Mg or Ca; R 1 and R 2 : 1-8C alkyl (optionally aryl substituted), benzyl (optionally alkyl or halogen substituted); R 1+R 2 : -C(R 3)(R 4)- or -CH(R 5)CH(R 6)-; R 3-R 6 : H or 1-6C alkyl, or aryl(optionally alkyl substituted);or R 5+R 6 : -(CH 2) 4-, -(CH 2) 5- or -(CH 2) 6-; R 7-R 9 : H or 1-8C alkyl. 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Preparing hydroxytyrosol involves reacting substituted benzene diol derivative of formula (I) with an aluminum compound of formula AlR 7R 8R 9; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solvent; and removing the organic solvent. X : CH 2OH or CH 2OM; M : Li, Na, K, Mg or Ca; R 1 and R 2 : 1-8C alkyl (optionally aryl substituted), benzyl (optionally alkyl or halogen substituted); R 1+R 2 : -C(R 3)(R 4)- or -CH(R 5)CH(R 6)-; R 3-R 6 : H or 1-6C alkyl, or aryl(optionally alkyl substituted);or R 5+R 6 : -(CH 2) 4-, -(CH 2) 5- or -(CH 2) 6-; R 7-R 9 : H or 1-8C alkyl. [Image] ACTIVITY : Antiinflammatory; Antimicrobial; Antibacterial; Neuroprotective; Apoptotic.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNANKMpPTi0uVkjLL1IoyUhVKChKLUgsSizJzM9TyE9TyKhMKcqvqCypLMovzs_hYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgFG5uYmlgaWTobGRCgBALHFKn4</recordid><startdate>20150812</startdate><enddate>20150812</enddate><creator>FLEISCHMANN, GERALD</creator><creator>KRÜGER, BENNO</creator><creator>PETERSEN, HERMANN</creator><scope>EVB</scope></search><sort><creationdate>20150812</creationdate><title>Process for the preparation of hydroxytyrosol</title><author>FLEISCHMANN, GERALD ; KRÜGER, BENNO ; PETERSEN, HERMANN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2774909B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2015</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>FLEISCHMANN, GERALD</creatorcontrib><creatorcontrib>KRÜGER, BENNO</creatorcontrib><creatorcontrib>PETERSEN, HERMANN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FLEISCHMANN, GERALD</au><au>KRÜGER, BENNO</au><au>PETERSEN, HERMANN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for the preparation of hydroxytyrosol</title><date>2015-08-12</date><risdate>2015</risdate><abstract>Preparing hydroxytyrosol involves reacting substituted benzene diol derivative with an aluminum compound; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solvent; and removing the organic solvent. Preparing hydroxytyrosol involves reacting substituted benzene diol derivative of formula (I) with an aluminum compound of formula AlR 7R 8R 9; adding an aqueous solution of hydroxycarboxylic acid to form a clear homogeneous acidic solution having pH less than 3; extracting hydroxytyrosol from the acidic solution using an organic solvent; and removing the organic solvent. X : CH 2OH or CH 2OM; M : Li, Na, K, Mg or Ca; R 1 and R 2 : 1-8C alkyl (optionally aryl substituted), benzyl (optionally alkyl or halogen substituted); R 1+R 2 : -C(R 3)(R 4)- or -CH(R 5)CH(R 6)-; R 3-R 6 : H or 1-6C alkyl, or aryl(optionally alkyl substituted);or R 5+R 6 : -(CH 2) 4-, -(CH 2) 5- or -(CH 2) 6-; R 7-R 9 : H or 1-8C alkyl. [Image] ACTIVITY : Antiinflammatory; Antimicrobial; Antibacterial; Neuroprotective; Apoptotic.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Process for the preparation of hydroxytyrosol |
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