INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS

The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition assoc...

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Hauptverfasser: WHITEHOUSE, DARREN, VAN ZANDT, MICHAEL, GOLEBIOWSKI, ADAM, RYDER, TODD, BECKETT, RAYMOND PAUL, JI, MIN KOO
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creator WHITEHOUSE, DARREN
VAN ZANDT, MICHAEL
GOLEBIOWSKI, ADAM
RYDER, TODD
BECKETT, RAYMOND PAUL
JI, MIN KOO
description The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition associated with arginase activity.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS
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