Methods and reagents for efficient and targeted gene transfer to cells of monocyte-macrophage lineage

Methods and reagents for efficient and targeted gene transfer to cells of monocyte-macrophage lineage

The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the shor...

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Hauptverfasser: RIO FERNANDEZ, ADOLFO, FERNANDEZ GIMENO, ESTER, GASSULL DURO, MIQUEL ANGEL, CHILLON RODRIGUEZ, MIGUEL
Format: Patent
Sprache:eng ; fre ; ger
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BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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creator RIO FERNANDEZ, ADOLFO
FERNANDEZ GIMENO, ESTER
GASSULL DURO, MIQUEL ANGEL
CHILLON RODRIGUEZ, MIGUEL
description The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic Ad40 to transfer genetic material to the target CD14+ mononuclear cells.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title Methods and reagents for efficient and targeted gene transfer to cells of monocyte-macrophage lineage
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