OCTAPEPTIDE, RADIOPHARMACEUTICAL AGENT BASED THEREON AND METHOD FOR DIAGNOSING TUMORS

The invention relates to octapeptides being octreotide derivatives and also to imaging agents based on it used to diagnose tumours, i.e. in chemistry and medicine. Octapeptide being an octreotide derivative has common formula (1): where X and Y are H, or chelating group, namely OTA, covalently bound...

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Bibliographische Detailangaben
Hauptverfasser:	OVCHINNIKOV, MIKHAIL VLADIMIROVICH, RABINOVICH, EDUARD ZINOVIEVICH, NAZARENKO, ANNA BORISOVNA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The invention relates to octapeptides being octreotide derivatives and also to imaging agents based on it used to diagnose tumours, i.e. in chemistry and medicine. Octapeptide being an octreotide derivative has common formula (1): where X and Y are H, or chelating group, namely OTA, covalently bound to ± - or µ-amino groups of N end lysine. Octapeptide with formula (1) forms a chelating complex with radionuclides, e.g. in the form of gallium isotopes 68 Ga , 66 Ga, 67 Ga to obtain the imaging agent. The imaging agent is used for diagnosing tumours expressing somatostatine receptors or their metastases. 3 non-protected formulas, 1 protected formula, 8 examples, 3 tables, 1 figure