CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE
The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ±-crystalline form, with a mass ratio of 9-phenyl-sym-octahydroselenoxanthene:cyclodextrin of from 1:3 to 1:30 or 9-phenyl-sym-octahydroselenoxanthene:arabinog...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | TSYB, ANATOLIY FEDOROVICH GONCHAROVA, ANNA YAKOVLEVNA PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH ERIMBETOV, KENES TAGAYEVICH VOROBYEV, ILYA VLADIMIROVICH ROZIEV, RAHIMDZHAN AHMETDZHANOVICH |
| description | The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ±-crystalline form, with a mass ratio of 9-phenyl-sym-octahydroselenoxanthene:cyclodextrin of from 1:3 to 1:30 or 9-phenyl-sym-octahydroselenoxanthene:arabinogalactan of from 1:10 to 1:20. The clathrate complex may be in crystalline form, possibly in the form of nano-particles with a size of less than 100 nm. In the clathrate complex, cyclodextrin is selected from ±-, ²-, ³- or hydroxypropyl-²-cyclodextrin, primarily ²-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2679584B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2679584B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2679584B13</originalsourceid><addsrcrecordid>eNqNiksOgjAQQNm4MOod5gJd-IflUAZLUjqkTCLdSIipK6MkeP_IwgO4esl7b5nctEUxHoVAc91Y6oBL0EFbLqgTXzlgD-gxrxxf0KIWdHCtxECmGkMuWNWGWvHsTSg8t2TJcYdO5kjrZPEYnlPc_LhKoCTRRsXx3cdpHO7xFT89NbvTOTumh3y7_2P5AvekMyk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE</title><source>esp@cenet</source><creator>TSYB, ANATOLIY FEDOROVICH ; GONCHAROVA, ANNA YAKOVLEVNA ; PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH ; ERIMBETOV, KENES TAGAYEVICH ; VOROBYEV, ILYA VLADIMIROVICH ; ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</creator><creatorcontrib>TSYB, ANATOLIY FEDOROVICH ; GONCHAROVA, ANNA YAKOVLEVNA ; PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH ; ERIMBETOV, KENES TAGAYEVICH ; VOROBYEV, ILYA VLADIMIROVICH ; ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</creatorcontrib><description>The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ±-crystalline form, with a mass ratio of 9-phenyl-sym-octahydroselenoxanthene:cyclodextrin of from 1:3 to 1:30 or 9-phenyl-sym-octahydroselenoxanthene:arabinogalactan of from 1:10 to 1:20. The clathrate complex may be in crystalline form, possibly in the form of nano-particles with a size of less than 100 nm. In the clathrate complex, cyclodextrin is selected from ±-, ²-, ³- or hydroxypropyl-²-cyclodextrin, primarily ²-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160803&DB=EPODOC&CC=EP&NR=2679584B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160803&DB=EPODOC&CC=EP&NR=2679584B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TSYB, ANATOLIY FEDOROVICH</creatorcontrib><creatorcontrib>GONCHAROVA, ANNA YAKOVLEVNA</creatorcontrib><creatorcontrib>PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH</creatorcontrib><creatorcontrib>ERIMBETOV, KENES TAGAYEVICH</creatorcontrib><creatorcontrib>VOROBYEV, ILYA VLADIMIROVICH</creatorcontrib><creatorcontrib>ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</creatorcontrib><title>CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE</title><description>The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ±-crystalline form, with a mass ratio of 9-phenyl-sym-octahydroselenoxanthene:cyclodextrin of from 1:3 to 1:30 or 9-phenyl-sym-octahydroselenoxanthene:arabinogalactan of from 1:10 to 1:20. The clathrate complex may be in crystalline form, possibly in the form of nano-particles with a size of less than 100 nm. In the clathrate complex, cyclodextrin is selected from ±-, ²-, ³- or hydroxypropyl-²-cyclodextrin, primarily ²-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNiksOgjAQQNm4MOod5gJd-IflUAZLUjqkTCLdSIipK6MkeP_IwgO4esl7b5nctEUxHoVAc91Y6oBL0EFbLqgTXzlgD-gxrxxf0KIWdHCtxECmGkMuWNWGWvHsTSg8t2TJcYdO5kjrZPEYnlPc_LhKoCTRRsXx3cdpHO7xFT89NbvTOTumh3y7_2P5AvekMyk</recordid><startdate>20160803</startdate><enddate>20160803</enddate><creator>TSYB, ANATOLIY FEDOROVICH</creator><creator>GONCHAROVA, ANNA YAKOVLEVNA</creator><creator>PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH</creator><creator>ERIMBETOV, KENES TAGAYEVICH</creator><creator>VOROBYEV, ILYA VLADIMIROVICH</creator><creator>ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</creator><scope>EVB</scope></search><sort><creationdate>20160803</creationdate><title>CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE</title><author>TSYB, ANATOLIY FEDOROVICH ; GONCHAROVA, ANNA YAKOVLEVNA ; PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH ; ERIMBETOV, KENES TAGAYEVICH ; VOROBYEV, ILYA VLADIMIROVICH ; ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2679584B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>TSYB, ANATOLIY FEDOROVICH</creatorcontrib><creatorcontrib>GONCHAROVA, ANNA YAKOVLEVNA</creatorcontrib><creatorcontrib>PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH</creatorcontrib><creatorcontrib>ERIMBETOV, KENES TAGAYEVICH</creatorcontrib><creatorcontrib>VOROBYEV, ILYA VLADIMIROVICH</creatorcontrib><creatorcontrib>ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TSYB, ANATOLIY FEDOROVICH</au><au>GONCHAROVA, ANNA YAKOVLEVNA</au><au>PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH</au><au>ERIMBETOV, KENES TAGAYEVICH</au><au>VOROBYEV, ILYA VLADIMIROVICH</au><au>ROZIEV, RAHIMDZHAN AHMETDZHANOVICH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE</title><date>2016-08-03</date><risdate>2016</risdate><abstract>The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ±-crystalline form, with a mass ratio of 9-phenyl-sym-octahydroselenoxanthene:cyclodextrin of from 1:3 to 1:30 or 9-phenyl-sym-octahydroselenoxanthene:arabinogalactan of from 1:10 to 1:20. The clathrate complex may be in crystalline form, possibly in the form of nano-particles with a size of less than 100 nm. In the clathrate complex, cyclodextrin is selected from ±-, ²-, ³- or hydroxypropyl-²-cyclodextrin, primarily ²-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP2679584B1 |
| source | esp@cenet |
| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T14%3A01%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=TSYB,%20ANATOLIY%20FEDOROVICH&rft.date=2016-08-03&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP2679584B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |