HOMO- AND HETERO-POLYAMINO-ACID DERIVATIVES OF FULLERENE C60, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITIONS BASED ON SAID DERIVATIVES
The invention relates to the pharmaceutical industry and to medicine, specifically to novel homo- and hetero-polyamino-acid derivatives of fullerene C 60 of general formula: C 60 (H) x {NH(CH 2 ) n COO-} x {NH 3 + (L)COOH)} x , where n = 2-5, x = 3, L = -(CH 2 ) m , where m = 1-5, or -CO(CH 2 ) k CH...
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| creator | SUVOROVA, OLGA NIKOLAEVNA SHVARTSMAN, IAKOV YUDELEVICH RASNETSOV, LEV DAVIDOVICH |
| description | The invention relates to the pharmaceutical industry and to medicine, specifically to novel homo- and hetero-polyamino-acid derivatives of fullerene C 60 of general formula: C 60 (H) x {NH(CH 2 ) n COO-} x {NH 3 + (L)COOH)} x , where n = 2-5, x = 3, L = -(CH 2 ) m , where m = 1-5, or -CO(CH 2 ) k CH(NH 2 )-, where k = 1-2, characterized in that the compounds comprise covalently bonded amino-acid groups and polar ionic forms of the amino acids, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions based on same. The method for producing homo- and hetero-polyamino-acid derivatives of fullerene is based on the reaction of a nucleophilic bond of amino acids to fullerene, forming covalently bonded amino-acid derivatives of fullerene, with the subsequent introduction of polar ionic forms of the amino acids. A pharmaceutical composition comprises, as active substance, homo- and hetero-polyamino-acid derivatives of fullerene of formula
C 60 (H) x {NH(CH 2 ) n COO-} x {NH 3 + (L)COOH)} x , where n = 2-5, x = 3, L = -(CH 2 ) m , where m = 1-5, or -CO(CH 2 ) k CH(NH 2 )-, where k = 1-2. |
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C 60 (H) x {NH(CH 2 ) n COO-} x {NH 3 + (L)COOH)} x , where n = 2-5, x = 3, L = -(CH 2 ) m , where m = 1-5, or -CO(CH 2 ) k CH(NH 2 )-, where k = 1-2.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HOMO- AND HETERO-POLYAMINO-ACID DERIVATIVES OF FULLERENE C60, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITIONS BASED ON SAID DERIVATIVES |
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