PROCESS FOR PREPARING AZOMETHINES FROM ALPHA-OXOCARBOXYLATES, AMINES AND ARYL BROMIDES
A process for preparing azomethines of the general formula (V) where R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and R 1 is an optio...
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| Format: | Patent |
| Sprache: | eng ; fre ; ger |
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| Zusammenfassung: | A process for preparing azomethines of the general formula (V)
where
R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and
R 1 is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms,
R 2 is hydrogen or an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted cycloalkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms
by reacting alpha-oxo carboxylates of the general formula (I)
where
n is a number in the range from 1 to 6,
M (n+) is a cation,
with aryl bromides of the general formula (IV)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 -Br€ƒ€ƒ€ƒ€ƒ€ƒ(IV)
and amines of the general formula (II)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 2 -NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(II)
via the alpha-iminocarboxylate intermediate of the general formula (III),
in the presence of two transition metals or compounds thereof as catalyst, is described. |
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