NAPHTHYRIDINE DERIVATIVE
The present invention provides, for example, the following compound: wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted, ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the lik...
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| creator | MITSUOKA, YASUNORI KOORIYAMA, YUUJI |
| description | The present invention provides, for example, the following compound:
wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted,
ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the like,
R 2a , R 2b , R 4a and R 4b are each independently hydrogen or substituted or unsubstituted alkyl or the like,
its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid 6 production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid ß proteins. |
| format | Patent |
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wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted,
ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the like,
R 2a , R 2b , R 4a and R 4b are each independently hydrogen or substituted or unsubstituted alkyl or the like,
its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid 6 production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid ß proteins.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130904&DB=EPODOC&CC=EP&NR=2634186A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130904&DB=EPODOC&CC=EP&NR=2634186A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MITSUOKA, YASUNORI</creatorcontrib><creatorcontrib>KOORIYAMA, YUUJI</creatorcontrib><title>NAPHTHYRIDINE DERIVATIVE</title><description>The present invention provides, for example, the following compound:
wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted,
ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the like,
R 2a , R 2b , R 4a and R 4b are each independently hydrogen or substituted or unsubstituted alkyl or the like,
its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid 6 production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid ß proteins.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJDwcwzwCPGIDPJ08fRzVXBxDfIMcwzxDHPlYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgFGZsYmhhZmjobGRCgBAM4sH40</recordid><startdate>20130904</startdate><enddate>20130904</enddate><creator>MITSUOKA, YASUNORI</creator><creator>KOORIYAMA, YUUJI</creator><scope>EVB</scope></search><sort><creationdate>20130904</creationdate><title>NAPHTHYRIDINE DERIVATIVE</title><author>MITSUOKA, YASUNORI ; KOORIYAMA, YUUJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2634186A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MITSUOKA, YASUNORI</creatorcontrib><creatorcontrib>KOORIYAMA, YUUJI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MITSUOKA, YASUNORI</au><au>KOORIYAMA, YUUJI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NAPHTHYRIDINE DERIVATIVE</title><date>2013-09-04</date><risdate>2013</risdate><abstract>The present invention provides, for example, the following compound:
wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted,
ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the like,
R 2a , R 2b , R 4a and R 4b are each independently hydrogen or substituted or unsubstituted alkyl or the like,
its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid 6 production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid ß proteins.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NAPHTHYRIDINE DERIVATIVE |
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