Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl...
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| creator | ITOH, NAOHIRO SUZUKI, SHINJI YASUI, KEN KOBAYASHI, NAOTAKE YUKIMASA, AKIRA KANDA, YASUHIKO UEDA, KAZUO SAKAGUCHI, GAKU KORIYAMA, YUJI HORI, AKIHIRO KATO, AKIRA HARAGUCHI, HIDEKAZU |
| description | A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I):
wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;
E is lower alkylene;
X is S, O, or NR 1 ;
R 1 is a hydrogen atom or lower alkyl;
R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom,
halogen, or hydroxy etc.;
n and m are each independently an integer of 0 to 3;
n+m is an integer of 0 to 3;
R 5 is a hydrogen atom or substituted lower alkyl;
its pharmaceutically acceptable salt, or a solvate thereof. |
| format | Patent |
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wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;
E is lower alkylene;
X is S, O, or NR 1 ;
R 1 is a hydrogen atom or lower alkyl;
R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom,
halogen, or hydroxy etc.;
n and m are each independently an integer of 0 to 3;
n+m is an integer of 0 to 3;
R 5 is a hydrogen atom or substituted lower alkyl;
its pharmaceutically acceptable salt, or a solvate thereof.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160330&DB=EPODOC&CC=EP&NR=2597087B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160330&DB=EPODOC&CC=EP&NR=2597087B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ITOH, NAOHIRO</creatorcontrib><creatorcontrib>SUZUKI, SHINJI</creatorcontrib><creatorcontrib>YASUI, KEN</creatorcontrib><creatorcontrib>KOBAYASHI, NAOTAKE</creatorcontrib><creatorcontrib>YUKIMASA, AKIRA</creatorcontrib><creatorcontrib>KANDA, YASUHIKO</creatorcontrib><creatorcontrib>UEDA, KAZUO</creatorcontrib><creatorcontrib>SAKAGUCHI, GAKU</creatorcontrib><creatorcontrib>KORIYAMA, YUJI</creatorcontrib><creatorcontrib>HORI, AKIHIRO</creatorcontrib><creatorcontrib>KATO, AKIRA</creatorcontrib><creatorcontrib>HARAGUCHI, HIDEKAZU</creatorcontrib><title>Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors</title><description>A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I):
wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;
E is lower alkylene;
X is S, O, or NR 1 ;
R 1 is a hydrogen atom or lower alkyl;
R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom,
halogen, or hydroxy etc.;
n and m are each independently an integer of 0 to 3;
n+m is an integer of 0 to 3;
R 5 is a hydrogen atom or substituted lower alkyl;
its pharmaceutically acceptable salt, or a solvate thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBwycyoTCnKz69IrMrMS1VIzEtRKEktKUoEixZUFmXmZqaAJFJSizLLEksyy1KLFRKLFZwcnV0VDBUy8zIykzJL8ouKeRhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJvGuAkamluYGFuZOhMRFKAHwxNDo</recordid><startdate>20160330</startdate><enddate>20160330</enddate><creator>ITOH, NAOHIRO</creator><creator>SUZUKI, SHINJI</creator><creator>YASUI, KEN</creator><creator>KOBAYASHI, NAOTAKE</creator><creator>YUKIMASA, AKIRA</creator><creator>KANDA, YASUHIKO</creator><creator>UEDA, KAZUO</creator><creator>SAKAGUCHI, GAKU</creator><creator>KORIYAMA, YUJI</creator><creator>HORI, AKIHIRO</creator><creator>KATO, AKIRA</creator><creator>HARAGUCHI, HIDEKAZU</creator><scope>EVB</scope></search><sort><creationdate>20160330</creationdate><title>Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors</title><author>ITOH, NAOHIRO ; SUZUKI, SHINJI ; YASUI, KEN ; KOBAYASHI, NAOTAKE ; YUKIMASA, AKIRA ; KANDA, YASUHIKO ; UEDA, KAZUO ; SAKAGUCHI, GAKU ; KORIYAMA, YUJI ; HORI, AKIHIRO ; KATO, AKIRA ; HARAGUCHI, HIDEKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2597087B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ITOH, NAOHIRO</creatorcontrib><creatorcontrib>SUZUKI, SHINJI</creatorcontrib><creatorcontrib>YASUI, KEN</creatorcontrib><creatorcontrib>KOBAYASHI, NAOTAKE</creatorcontrib><creatorcontrib>YUKIMASA, AKIRA</creatorcontrib><creatorcontrib>KANDA, YASUHIKO</creatorcontrib><creatorcontrib>UEDA, KAZUO</creatorcontrib><creatorcontrib>SAKAGUCHI, GAKU</creatorcontrib><creatorcontrib>KORIYAMA, YUJI</creatorcontrib><creatorcontrib>HORI, AKIHIRO</creatorcontrib><creatorcontrib>KATO, AKIRA</creatorcontrib><creatorcontrib>HARAGUCHI, HIDEKAZU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ITOH, NAOHIRO</au><au>SUZUKI, SHINJI</au><au>YASUI, KEN</au><au>KOBAYASHI, NAOTAKE</au><au>YUKIMASA, AKIRA</au><au>KANDA, YASUHIKO</au><au>UEDA, KAZUO</au><au>SAKAGUCHI, GAKU</au><au>KORIYAMA, YUJI</au><au>HORI, AKIHIRO</au><au>KATO, AKIRA</au><au>HARAGUCHI, HIDEKAZU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors</title><date>2016-03-30</date><risdate>2016</risdate><abstract>A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I):
wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;
E is lower alkylene;
X is S, O, or NR 1 ;
R 1 is a hydrogen atom or lower alkyl;
R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom,
halogen, or hydroxy etc.;
n and m are each independently an integer of 0 to 3;
n+m is an integer of 0 to 3;
R 5 is a hydrogen atom or substituted lower alkyl;
its pharmaceutically acceptable salt, or a solvate thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors |
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