PROCESS FOR PREPARING SULFONAMIDO-BENZOFURAN DERIVATIVES

PROCESS FOR PREPARING SULFONAMIDO-BENZOFURAN DERIVATIVES

The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl group and R1 and R2 represent hydrogen or an alkyl or aryl group. According to the invention, the compounds of formula I are prepared by coupli...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAYRON, PHILIPPE, PAUL, PRIEM, THOMAS
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl group and R1 and R2 represent hydrogen or an alkyl or aryl group. According to the invention, the compounds of formula I are prepared by coupling a benzofuran derivative of general formula II, where X represents chlorine, bromine or iodine or a sulfonate group: formula (II) with a sulfonamide derivative of formula R-SO2-NH2, in the presence of a basic agent and of a catalyst system formed from a complex between a palladium compound and a ligand.