Isomerisation method
Preparation of 1,4-trans substituted cyclohexane compound (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. Preparation of 1,4-trans substituted cyclohexane compound of formula (I) comprises converting 1,4-cis-cycl...
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| creator | MAILLARD, DAVID WAECHTLER, ANDREAS KRATTINGER, PHILIPP KRIEGBAUM, MARKUS SCHAEFER, RALF |
| description | Preparation of 1,4-trans substituted cyclohexane compound (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. Preparation of 1,4-trans substituted cyclohexane compound of formula (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. R 1>unsubstituted, linear up to 9C-alkyl or -CH(CH 3)CH 3; R 2>H, halo, up to 9C-alkyl, up to 9 C-perfluoroalkyl, up to 9C-perfluoroalkoxy or up to 9C-alkoxy (when s is greater than 0); m : 1 or 2; n, s : 0-2; p : 1-4; q : 0-4; A 1>trans-1,4-cyclohexylene; Z 1>-(CH 2) t; and t : 0-4. [Image].
Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von trans-1,4-disubstituierten Cyclohexanverbindungen mit mindestens einem von Benzol abgeleiteten Rest in 1- oder 4-Stellung, das einen Isomerisierungsschritt umfasst, der einen oder mehrere cis-konfigurierte Cyclohenxanringe unter Verwendung einer starken Säure und in Gegenwart einer zusätzlichen Carbokationen bildenden Verbindung in die trans-Konfiguration überführt. |
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Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von trans-1,4-disubstituierten Cyclohexanverbindungen mit mindestens einem von Benzol abgeleiteten Rest in 1- oder 4-Stellung, das einen Isomerisierungsschritt umfasst, der einen oder mehrere cis-konfigurierte Cyclohenxanringe unter Verwendung einer starken Säure und in Gegenwart einer zusätzlichen Carbokationen bildenden Verbindung in die trans-Konfiguration überführt.</description><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121212&DB=EPODOC&CC=EP&NR=2532641A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121212&DB=EPODOC&CC=EP&NR=2532641A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAILLARD, DAVID</creatorcontrib><creatorcontrib>WAECHTLER, ANDREAS</creatorcontrib><creatorcontrib>KRATTINGER, PHILIPP</creatorcontrib><creatorcontrib>KRIEGBAUM, MARKUS</creatorcontrib><creatorcontrib>SCHAEFER, RALF</creatorcontrib><title>Isomerisation method</title><description>Preparation of 1,4-trans substituted cyclohexane compound (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. Preparation of 1,4-trans substituted cyclohexane compound of formula (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. R 1>unsubstituted, linear up to 9C-alkyl or -CH(CH 3)CH 3; R 2>H, halo, up to 9C-alkyl, up to 9 C-perfluoroalkyl, up to 9C-perfluoroalkoxy or up to 9C-alkoxy (when s is greater than 0); m : 1 or 2; n, s : 0-2; p : 1-4; q : 0-4; A 1>trans-1,4-cyclohexylene; Z 1>-(CH 2) t; and t : 0-4. [Image].
Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von trans-1,4-disubstituierten Cyclohexanverbindungen mit mindestens einem von Benzol abgeleiteten Rest in 1- oder 4-Stellung, das einen Isomerisierungsschritt umfasst, der einen oder mehrere cis-konfigurierte Cyclohenxanringe unter Verwendung einer starken Säure und in Gegenwart einer zusätzlichen Carbokationen bildenden Verbindung in die trans-Konfiguration überführt.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBDxLM7PTS3KLE4syczPU8hNLcnIT-FhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAUamxkZmJoaOhsZEKAEAKGMgmA</recordid><startdate>20121212</startdate><enddate>20121212</enddate><creator>MAILLARD, DAVID</creator><creator>WAECHTLER, ANDREAS</creator><creator>KRATTINGER, PHILIPP</creator><creator>KRIEGBAUM, MARKUS</creator><creator>SCHAEFER, RALF</creator><scope>EVB</scope></search><sort><creationdate>20121212</creationdate><title>Isomerisation method</title><author>MAILLARD, DAVID ; WAECHTLER, ANDREAS ; KRATTINGER, PHILIPP ; KRIEGBAUM, MARKUS ; SCHAEFER, RALF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2532641A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2012</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MAILLARD, DAVID</creatorcontrib><creatorcontrib>WAECHTLER, ANDREAS</creatorcontrib><creatorcontrib>KRATTINGER, PHILIPP</creatorcontrib><creatorcontrib>KRIEGBAUM, MARKUS</creatorcontrib><creatorcontrib>SCHAEFER, RALF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAILLARD, DAVID</au><au>WAECHTLER, ANDREAS</au><au>KRATTINGER, PHILIPP</au><au>KRIEGBAUM, MARKUS</au><au>SCHAEFER, RALF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Isomerisation method</title><date>2012-12-12</date><risdate>2012</risdate><abstract>Preparation of 1,4-trans substituted cyclohexane compound (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. Preparation of 1,4-trans substituted cyclohexane compound of formula (I) comprises converting 1,4-cis-cyclohexane compounds in the presence of a strong acid and an additional carbocation forming compound. R 1>unsubstituted, linear up to 9C-alkyl or -CH(CH 3)CH 3; R 2>H, halo, up to 9C-alkyl, up to 9 C-perfluoroalkyl, up to 9C-perfluoroalkoxy or up to 9C-alkoxy (when s is greater than 0); m : 1 or 2; n, s : 0-2; p : 1-4; q : 0-4; A 1>trans-1,4-cyclohexylene; Z 1>-(CH 2) t; and t : 0-4. [Image].
Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von trans-1,4-disubstituierten Cyclohexanverbindungen mit mindestens einem von Benzol abgeleiteten Rest in 1- oder 4-Stellung, das einen Isomerisierungsschritt umfasst, der einen oder mehrere cis-konfigurierte Cyclohenxanringe unter Verwendung einer starken Säure und in Gegenwart einer zusätzlichen Carbokationen bildenden Verbindung in die trans-Konfiguration überführt.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Isomerisation method |
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