IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 2
The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine...
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| creator | HUDSON, PETER JOHN TAMVAKIS, DEBRA WHEATCROFT, MICHAEL PAUL TURATTI, FABIO |
| description | The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound. |
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Preferably the protein comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130522&DB=EPODOC&CC=EP&NR=2516462A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130522&DB=EPODOC&CC=EP&NR=2516462A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUDSON, PETER JOHN</creatorcontrib><creatorcontrib>TAMVAKIS, DEBRA</creatorcontrib><creatorcontrib>WHEATCROFT, MICHAEL PAUL</creatorcontrib><creatorcontrib>TURATTI, FABIO</creatorcontrib><title>IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 2</title><description>The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDy9PUN9fPXdfb38wp1dwxxDVZw9HNR8HUN8fB3CVZw8w9SCAjydwl19vRzVwjxcPVVMOJhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAUamhmYmZkaOJsZEKAEAJgQmSQ</recordid><startdate>20130522</startdate><enddate>20130522</enddate><creator>HUDSON, PETER JOHN</creator><creator>TAMVAKIS, DEBRA</creator><creator>WHEATCROFT, MICHAEL PAUL</creator><creator>TURATTI, FABIO</creator><scope>EVB</scope></search><sort><creationdate>20130522</creationdate><title>IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 2</title><author>HUDSON, PETER JOHN ; TAMVAKIS, DEBRA ; WHEATCROFT, MICHAEL PAUL ; TURATTI, FABIO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2516462A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HUDSON, PETER JOHN</creatorcontrib><creatorcontrib>TAMVAKIS, DEBRA</creatorcontrib><creatorcontrib>WHEATCROFT, MICHAEL PAUL</creatorcontrib><creatorcontrib>TURATTI, FABIO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HUDSON, PETER JOHN</au><au>TAMVAKIS, DEBRA</au><au>WHEATCROFT, MICHAEL PAUL</au><au>TURATTI, FABIO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 2</title><date>2013-05-22</date><risdate>2013</risdate><abstract>The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 2 |
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