Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1)

The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to...

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Hauptverfasser:	KELLERMANN, SIRID-AIMEE, WICKMAN, GRANT RAYMOND, AMUNDSON, KARIN KRISTINA, HU-LOWE, DANA DAN, ZHANG, JINGCHUAN, BELOUSKI, SHELLEY SIMS, JIANG, XIN, KARLICEK, SHANNON MARIE, WANG, JIANYING, THOMSON, JAMES ARTHUR, NORTH, MICHAEL AIDAN, BEDIAN, VAHE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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