Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1)

The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to...

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Hauptverfasser: KELLERMANN, SIRID-AIMEE, WICKMAN, GRANT RAYMOND, AMUNDSON, KARIN KRISTINA, HU-LOWE, DANA DAN, ZHANG, JINGCHUAN, BELOUSKI, SHELLEY SIMS, JIANG, XIN, KARLICEK, SHANNON MARIE, WANG, JIANYING, THOMSON, JAMES ARTHUR, NORTH, MICHAEL AIDAN, BEDIAN, VAHE
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The disclosure also relates to transgenic animals or plants comprising nucleic acid molecules of the present disclosure.