Pharmaceutical compositions comprising fentanyl for intranasal delivery
This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of (i) fentanyl or a pharmaceutically acceptable salt thereof and (ii) a pectin having a degree of esterification (DE value) of less than 30% pr...
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| creator | Smith, Alan Lafferty, William Columbus Ian Castile, Jonathan David Watts, Peter James |
| description | This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. |
| format | Patent |
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(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</description><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190227&DB=EPODOC&CC=EP&NR=2436375B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190227&DB=EPODOC&CC=EP&NR=2436375B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Smith, Alan</creatorcontrib><creatorcontrib>Lafferty, William Columbus Ian</creatorcontrib><creatorcontrib>Castile, Jonathan David</creatorcontrib><creatorcontrib>Watts, Peter James</creatorcontrib><title>Pharmaceutical compositions comprising fentanyl for intranasal delivery</title><description>This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAPyEgsyk1MTi0tyUxOzFFIzs8tyC_OLMnMzysGc4oyizPz0hXSUvNKEvMqcxTS8osUMvNKihLzEouB6lNSczLLUosqeRhY0xJzilN5oTQ3g4Kba4izh25qQX58anEB0Ia81JJ41wAjE2MzY3NTJ0NjIpQAAKEENNI</recordid><startdate>20190227</startdate><enddate>20190227</enddate><creator>Smith, Alan</creator><creator>Lafferty, William Columbus Ian</creator><creator>Castile, Jonathan David</creator><creator>Watts, Peter James</creator><scope>EVB</scope></search><sort><creationdate>20190227</creationdate><title>Pharmaceutical compositions comprising fentanyl for intranasal delivery</title><author>Smith, Alan ; Lafferty, William Columbus Ian ; Castile, Jonathan David ; Watts, Peter James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2436375B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Smith, Alan</creatorcontrib><creatorcontrib>Lafferty, William Columbus Ian</creatorcontrib><creatorcontrib>Castile, Jonathan David</creatorcontrib><creatorcontrib>Watts, Peter James</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Smith, Alan</au><au>Lafferty, William Columbus Ian</au><au>Castile, Jonathan David</au><au>Watts, Peter James</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pharmaceutical compositions comprising fentanyl for intranasal delivery</title><date>2019-02-27</date><risdate>2019</risdate><abstract>This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pharmaceutical compositions comprising fentanyl for intranasal delivery |
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