Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers

There is provided a composition comprising at least one mucoadhesive polymer that is capable of forming a hydrogel and at one least water soluble polymer, and one or more enzymes, microorganisms, or antibodies. The formulation forms a hydrogel in aqueous solution that has mucoadhesive properties and that is capable of releasing the enzymes, microorganisms, or antibodies over an extended period of time and/or of entrapping enzymes, microorganisms, or antibodies within the hydrogel that is active for an extended time.