Dipyridamole prolonged-release tablet
The present invention relates to a gastro-retentive, prolonged-release tablet formulation comprising in the intragranular phase a pharmaceutically active ingredient and a water-swellable polymer, and in the extragranular phase hydroxypropyl methyl cellulose (HPMC). The tablet of the present inventio...
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| Format: | Patent |
| Sprache: | eng ; fre ; ger |
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| Zusammenfassung: | The present invention relates to a gastro-retentive, prolonged-release tablet formulation comprising in the intragranular phase a pharmaceutically active ingredient and a water-swellable polymer, and in the extragranular phase hydroxypropyl methyl cellulose (HPMC). The tablet of the present invention is further characterized in that it contains a gas generating agent, thereby causing the tablet to float on the gastric juice. The tablet is particularly suitable for dipyridamole which is a drug that inhibits thrombus formation. The present invention thus provides an alternative to the commercially available dipyridamole containing pharmaceutical compositions marketed under the tradenames Aggrenox ® and Persantine ® . |
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