METAL COMPLEXES, A METHOD FOR PREPARING SAME, RADIOPHARMACEUTICAL MEANS BASED THEREON
The invention relates to the new metal complexes of the formula M(O) K H m A n- , wherein M is the isotope of Tc, Re, Sm, Lu, Y, H is the hydrogen, A 5- is the anion of the zoledronic acid, wherein, when M is the technetium, then K=1, m=1, n=2; when M is the rhenium, then K=1, m=1, n=2; when M is th...
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| creator | MIHAYLOV, OLEG ROTISLAVOVICH MALYSHEVA, ANNA OLEGOVNA NAZARENKO, MIHAIL EVGENIEVICH KLEMENTYEVA, OLGA EVGENIEVNA KODINA, GALINA EVGENIEVNA PERMINOV, SERGEI VLADIMIROVICH UVAROV, NIKOLAI ALEKSANDROVICH KORSUNSKY, VALENTIN NIKOLAEVICH FEDOROV, VLADIMIR EGOROVICH |
| description | The invention relates to the new metal complexes of the formula M(O) K H m A n- , wherein M is the isotope of Tc, Re, Sm, Lu, Y, H is the hydrogen, A 5- is the anion of the zoledronic acid, wherein, when M is the technetium, then K=1, m=1, n=2; when M is the rhenium, then K=1, m=1, n=2; when M is the samarium, lutetium, or yttrium, then K=0, m=2, n=3, and their pharmaceutically eligible salts, hydrates, or isomers. The invention also relates to the method of production of the metal complex, wherein the lyophilizate obtained by mixing the zoledronic acid and tin dichloride solutions in the hydrochloric acid under inert gas and adding a hydroxide of an alkaline metal is mixed with a salt of a metal from the isotopes group and a radionuclide solution. What is proposed is the radiopharmaceutical that contains the metal complexes, their pharmaceutically eligible salts, hydrates, or isomers, and antioxidant, and the method of production of the radiopharmaceutical, wherein the lyophilizate is mixed with the solution containing a salt of a metal from the isotopes group and the radionuclide solution. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2351758A4</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2351758A4</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2351758A43</originalsourceid><addsrcrecordid>eNqNi00KwjAUBrtxIeod3gHqQmux22fy1QSaH5IU3JUicSVaqPfHLjyAq4FhZl30Bok7Es74DjfEkpgWpZyk1gXyAZ6DtleKbFBSYKmdVxwMC_RJi-U1YBvpwhGSkkKAs9ti9Rifc979uCmoRRJqn6f3kOdpvOdX_gzwx6o-nOuGT9UfyRfQAC-0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METAL COMPLEXES, A METHOD FOR PREPARING SAME, RADIOPHARMACEUTICAL MEANS BASED THEREON</title><source>esp@cenet</source><creator>MIHAYLOV, OLEG ROTISLAVOVICH ; MALYSHEVA, ANNA OLEGOVNA ; NAZARENKO, MIHAIL EVGENIEVICH ; KLEMENTYEVA, OLGA EVGENIEVNA ; KODINA, GALINA EVGENIEVNA ; PERMINOV, SERGEI VLADIMIROVICH ; UVAROV, NIKOLAI ALEKSANDROVICH ; KORSUNSKY, VALENTIN NIKOLAEVICH ; FEDOROV, VLADIMIR EGOROVICH</creator><creatorcontrib>MIHAYLOV, OLEG ROTISLAVOVICH ; MALYSHEVA, ANNA OLEGOVNA ; NAZARENKO, MIHAIL EVGENIEVICH ; KLEMENTYEVA, OLGA EVGENIEVNA ; KODINA, GALINA EVGENIEVNA ; PERMINOV, SERGEI VLADIMIROVICH ; UVAROV, NIKOLAI ALEKSANDROVICH ; KORSUNSKY, VALENTIN NIKOLAEVICH ; FEDOROV, VLADIMIR EGOROVICH</creatorcontrib><description>The invention relates to the new metal complexes of the formula M(O) K H m A n- , wherein M is the isotope of Tc, Re, Sm, Lu, Y, H is the hydrogen, A 5- is the anion of the zoledronic acid, wherein, when M is the technetium, then K=1, m=1, n=2; when M is the rhenium, then K=1, m=1, n=2; when M is the samarium, lutetium, or yttrium, then K=0, m=2, n=3, and their pharmaceutically eligible salts, hydrates, or isomers. The invention also relates to the method of production of the metal complex, wherein the lyophilizate obtained by mixing the zoledronic acid and tin dichloride solutions in the hydrochloric acid under inert gas and adding a hydroxide of an alkaline metal is mixed with a salt of a metal from the isotopes group and a radionuclide solution. What is proposed is the radiopharmaceutical that contains the metal complexes, their pharmaceutically eligible salts, hydrates, or isomers, and antioxidant, and the method of production of the radiopharmaceutical, wherein the lyophilizate is mixed with the solution containing a salt of a metal from the isotopes group and the radionuclide solution.</description><language>eng ; fre ; ger</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120404&DB=EPODOC&CC=EP&NR=2351758A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120404&DB=EPODOC&CC=EP&NR=2351758A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MIHAYLOV, OLEG ROTISLAVOVICH</creatorcontrib><creatorcontrib>MALYSHEVA, ANNA OLEGOVNA</creatorcontrib><creatorcontrib>NAZARENKO, MIHAIL EVGENIEVICH</creatorcontrib><creatorcontrib>KLEMENTYEVA, OLGA EVGENIEVNA</creatorcontrib><creatorcontrib>KODINA, GALINA EVGENIEVNA</creatorcontrib><creatorcontrib>PERMINOV, SERGEI VLADIMIROVICH</creatorcontrib><creatorcontrib>UVAROV, NIKOLAI ALEKSANDROVICH</creatorcontrib><creatorcontrib>KORSUNSKY, VALENTIN NIKOLAEVICH</creatorcontrib><creatorcontrib>FEDOROV, VLADIMIR EGOROVICH</creatorcontrib><title>METAL COMPLEXES, A METHOD FOR PREPARING SAME, RADIOPHARMACEUTICAL MEANS BASED THEREON</title><description>The invention relates to the new metal complexes of the formula M(O) K H m A n- , wherein M is the isotope of Tc, Re, Sm, Lu, Y, H is the hydrogen, A 5- is the anion of the zoledronic acid, wherein, when M is the technetium, then K=1, m=1, n=2; when M is the rhenium, then K=1, m=1, n=2; when M is the samarium, lutetium, or yttrium, then K=0, m=2, n=3, and their pharmaceutically eligible salts, hydrates, or isomers. The invention also relates to the method of production of the metal complex, wherein the lyophilizate obtained by mixing the zoledronic acid and tin dichloride solutions in the hydrochloric acid under inert gas and adding a hydroxide of an alkaline metal is mixed with a salt of a metal from the isotopes group and a radionuclide solution. What is proposed is the radiopharmaceutical that contains the metal complexes, their pharmaceutically eligible salts, hydrates, or isomers, and antioxidant, and the method of production of the radiopharmaceutical, wherein the lyophilizate is mixed with the solution containing a salt of a metal from the isotopes group and the radionuclide solution.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi00KwjAUBrtxIeod3gHqQmux22fy1QSaH5IU3JUicSVaqPfHLjyAq4FhZl30Bok7Es74DjfEkpgWpZyk1gXyAZ6DtleKbFBSYKmdVxwMC_RJi-U1YBvpwhGSkkKAs9ti9Rifc979uCmoRRJqn6f3kOdpvOdX_gzwx6o-nOuGT9UfyRfQAC-0</recordid><startdate>20120404</startdate><enddate>20120404</enddate><creator>MIHAYLOV, OLEG ROTISLAVOVICH</creator><creator>MALYSHEVA, ANNA OLEGOVNA</creator><creator>NAZARENKO, MIHAIL EVGENIEVICH</creator><creator>KLEMENTYEVA, OLGA EVGENIEVNA</creator><creator>KODINA, GALINA EVGENIEVNA</creator><creator>PERMINOV, SERGEI VLADIMIROVICH</creator><creator>UVAROV, NIKOLAI ALEKSANDROVICH</creator><creator>KORSUNSKY, VALENTIN NIKOLAEVICH</creator><creator>FEDOROV, VLADIMIR EGOROVICH</creator><scope>EVB</scope></search><sort><creationdate>20120404</creationdate><title>METAL COMPLEXES, A METHOD FOR PREPARING SAME, RADIOPHARMACEUTICAL MEANS BASED THEREON</title><author>MIHAYLOV, OLEG ROTISLAVOVICH ; MALYSHEVA, ANNA OLEGOVNA ; NAZARENKO, MIHAIL EVGENIEVICH ; KLEMENTYEVA, OLGA EVGENIEVNA ; KODINA, GALINA EVGENIEVNA ; PERMINOV, SERGEI VLADIMIROVICH ; UVAROV, NIKOLAI ALEKSANDROVICH ; KORSUNSKY, VALENTIN NIKOLAEVICH ; FEDOROV, VLADIMIR EGOROVICH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2351758A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2012</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MIHAYLOV, OLEG ROTISLAVOVICH</creatorcontrib><creatorcontrib>MALYSHEVA, ANNA OLEGOVNA</creatorcontrib><creatorcontrib>NAZARENKO, MIHAIL EVGENIEVICH</creatorcontrib><creatorcontrib>KLEMENTYEVA, OLGA EVGENIEVNA</creatorcontrib><creatorcontrib>KODINA, GALINA EVGENIEVNA</creatorcontrib><creatorcontrib>PERMINOV, SERGEI VLADIMIROVICH</creatorcontrib><creatorcontrib>UVAROV, NIKOLAI ALEKSANDROVICH</creatorcontrib><creatorcontrib>KORSUNSKY, VALENTIN NIKOLAEVICH</creatorcontrib><creatorcontrib>FEDOROV, VLADIMIR EGOROVICH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MIHAYLOV, OLEG ROTISLAVOVICH</au><au>MALYSHEVA, ANNA OLEGOVNA</au><au>NAZARENKO, MIHAIL EVGENIEVICH</au><au>KLEMENTYEVA, OLGA EVGENIEVNA</au><au>KODINA, GALINA EVGENIEVNA</au><au>PERMINOV, SERGEI VLADIMIROVICH</au><au>UVAROV, NIKOLAI ALEKSANDROVICH</au><au>KORSUNSKY, VALENTIN NIKOLAEVICH</au><au>FEDOROV, VLADIMIR EGOROVICH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METAL COMPLEXES, A METHOD FOR PREPARING SAME, RADIOPHARMACEUTICAL MEANS BASED THEREON</title><date>2012-04-04</date><risdate>2012</risdate><abstract>The invention relates to the new metal complexes of the formula M(O) K H m A n- , wherein M is the isotope of Tc, Re, Sm, Lu, Y, H is the hydrogen, A 5- is the anion of the zoledronic acid, wherein, when M is the technetium, then K=1, m=1, n=2; when M is the rhenium, then K=1, m=1, n=2; when M is the samarium, lutetium, or yttrium, then K=0, m=2, n=3, and their pharmaceutically eligible salts, hydrates, or isomers. The invention also relates to the method of production of the metal complex, wherein the lyophilizate obtained by mixing the zoledronic acid and tin dichloride solutions in the hydrochloric acid under inert gas and adding a hydroxide of an alkaline metal is mixed with a salt of a metal from the isotopes group and a radionuclide solution. What is proposed is the radiopharmaceutical that contains the metal complexes, their pharmaceutically eligible salts, hydrates, or isomers, and antioxidant, and the method of production of the radiopharmaceutical, wherein the lyophilizate is mixed with the solution containing a salt of a metal from the isotopes group and the radionuclide solution.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METAL COMPLEXES, A METHOD FOR PREPARING SAME, RADIOPHARMACEUTICAL MEANS BASED THEREON |
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