SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA SECRETASE MODULATORS AND METHODS OF USE
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wh...
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| creator | WHITE, RYAN CHENG, ALAN C GORE, VIJAY KESHAV PATEL, VINOD F LIU, QINGYIAN HUANG, HONGBING MARX, ISAAC YUAN, CHESTER C QIAN, WENYUAN BRYAN, MARIAN C LA, DANIEL MA, VU VAN CHEN, JIAN J KREIMAN, CHARLES HUA, ZIHAO HUMAN, JASON B WEISS, MATTHEW EPSTEIN, OLEG AMEGADZIE, ALBERT DINEEN, THOMAS |
| description | The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2328903A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2328903A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2328903A13</originalsourceid><addsrcrecordid>eNqNyjEOwiAUgGEWB6Pe4V2giZZFR4RXS1J4hAdDp6YxOBltUu8fGTyA0zf8_1YEDjZSkzBFpUc9WA3R-htocoGyNwyK4YpJAaOOVUZwZPKgEsUavQGHqac6UgeZcS82j_m5lsPPnYAOk-6bsrynsi7zvbzKZ8LQyvZ8OUp1kn8sXye_LrA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA SECRETASE MODULATORS AND METHODS OF USE</title><source>esp@cenet</source><creator>WHITE, RYAN ; CHENG, ALAN C ; GORE, VIJAY KESHAV ; PATEL, VINOD F ; LIU, QINGYIAN ; HUANG, HONGBING ; MARX, ISAAC ; YUAN, CHESTER C ; QIAN, WENYUAN ; BRYAN, MARIAN C ; LA, DANIEL ; MA, VU VAN ; CHEN, JIAN J ; KREIMAN, CHARLES ; HUA, ZIHAO ; HUMAN, JASON B ; WEISS, MATTHEW ; EPSTEIN, OLEG ; AMEGADZIE, ALBERT ; DINEEN, THOMAS</creator><creatorcontrib>WHITE, RYAN ; CHENG, ALAN C ; GORE, VIJAY KESHAV ; PATEL, VINOD F ; LIU, QINGYIAN ; HUANG, HONGBING ; MARX, ISAAC ; YUAN, CHESTER C ; QIAN, WENYUAN ; BRYAN, MARIAN C ; LA, DANIEL ; MA, VU VAN ; CHEN, JIAN J ; KREIMAN, CHARLES ; HUA, ZIHAO ; HUMAN, JASON B ; WEISS, MATTHEW ; EPSTEIN, OLEG ; AMEGADZIE, ALBERT ; DINEEN, THOMAS</creatorcontrib><description>The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110608&DB=EPODOC&CC=EP&NR=2328903A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110608&DB=EPODOC&CC=EP&NR=2328903A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WHITE, RYAN</creatorcontrib><creatorcontrib>CHENG, ALAN C</creatorcontrib><creatorcontrib>GORE, VIJAY KESHAV</creatorcontrib><creatorcontrib>PATEL, VINOD F</creatorcontrib><creatorcontrib>LIU, QINGYIAN</creatorcontrib><creatorcontrib>HUANG, HONGBING</creatorcontrib><creatorcontrib>MARX, ISAAC</creatorcontrib><creatorcontrib>YUAN, CHESTER C</creatorcontrib><creatorcontrib>QIAN, WENYUAN</creatorcontrib><creatorcontrib>BRYAN, MARIAN C</creatorcontrib><creatorcontrib>LA, DANIEL</creatorcontrib><creatorcontrib>MA, VU VAN</creatorcontrib><creatorcontrib>CHEN, JIAN J</creatorcontrib><creatorcontrib>KREIMAN, CHARLES</creatorcontrib><creatorcontrib>HUA, ZIHAO</creatorcontrib><creatorcontrib>HUMAN, JASON B</creatorcontrib><creatorcontrib>WEISS, MATTHEW</creatorcontrib><creatorcontrib>EPSTEIN, OLEG</creatorcontrib><creatorcontrib>AMEGADZIE, ALBERT</creatorcontrib><creatorcontrib>DINEEN, THOMAS</creatorcontrib><title>SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA SECRETASE MODULATORS AND METHODS OF USE</title><description>The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. 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In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA SECRETASE MODULATORS AND METHODS OF USE |
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