4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE
The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(eth...
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creator | HANDSCHUH, SANDRA FIEGEN, DENNIS HOBBIE, SILKE HOFFMANN, MATTHIAS SATO, YAYOI SCHULER-METZ, ANNETTE KONO, TAKESHI SCHNAPP, ANDREAS |
description | The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds. |
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fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2313406B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2313406B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2313406B13</originalsourceid><addsrcrecordid>eNrjZPA20XXx9HUN8Yj0cfT19PMP8HD1i_RRCA51Cg7xDAkNcXVR8HMMCPEAKgjydPH0cw1WCPVzUQjxcPUMUggNdlVwDFbwdXXxdAZK8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeNcAI2NDYxMDMydDYyKUAAB03i2n</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><source>esp@cenet</source><creator>HANDSCHUH, SANDRA ; FIEGEN, DENNIS ; HOBBIE, SILKE ; HOFFMANN, MATTHIAS ; SATO, YAYOI ; SCHULER-METZ, ANNETTE ; KONO, TAKESHI ; SCHNAPP, ANDREAS</creator><creatorcontrib>HANDSCHUH, SANDRA ; FIEGEN, DENNIS ; HOBBIE, SILKE ; HOFFMANN, MATTHIAS ; SATO, YAYOI ; SCHULER-METZ, ANNETTE ; KONO, TAKESHI ; SCHNAPP, ANDREAS</creatorcontrib><description>The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150225&DB=EPODOC&CC=EP&NR=2313406B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150225&DB=EPODOC&CC=EP&NR=2313406B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANDSCHUH, SANDRA</creatorcontrib><creatorcontrib>FIEGEN, DENNIS</creatorcontrib><creatorcontrib>HOBBIE, SILKE</creatorcontrib><creatorcontrib>HOFFMANN, MATTHIAS</creatorcontrib><creatorcontrib>SATO, YAYOI</creatorcontrib><creatorcontrib>SCHULER-METZ, ANNETTE</creatorcontrib><creatorcontrib>KONO, TAKESHI</creatorcontrib><creatorcontrib>SCHNAPP, ANDREAS</creatorcontrib><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><description>The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPA20XXx9HUN8Yj0cfT19PMP8HD1i_RRCA51Cg7xDAkNcXVR8HMMCPEAKgjydPH0cw1WCPVzUQjxcPUMUggNdlVwDFbwdXXxdAZK8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeNcAI2NDYxMDMydDYyKUAAB03i2n</recordid><startdate>20150225</startdate><enddate>20150225</enddate><creator>HANDSCHUH, SANDRA</creator><creator>FIEGEN, DENNIS</creator><creator>HOBBIE, SILKE</creator><creator>HOFFMANN, MATTHIAS</creator><creator>SATO, YAYOI</creator><creator>SCHULER-METZ, ANNETTE</creator><creator>KONO, TAKESHI</creator><creator>SCHNAPP, ANDREAS</creator><scope>EVB</scope></search><sort><creationdate>20150225</creationdate><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><author>HANDSCHUH, SANDRA ; FIEGEN, DENNIS ; HOBBIE, SILKE ; HOFFMANN, MATTHIAS ; SATO, YAYOI ; SCHULER-METZ, ANNETTE ; KONO, TAKESHI ; SCHNAPP, ANDREAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2313406B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANDSCHUH, SANDRA</creatorcontrib><creatorcontrib>FIEGEN, DENNIS</creatorcontrib><creatorcontrib>HOBBIE, SILKE</creatorcontrib><creatorcontrib>HOFFMANN, MATTHIAS</creatorcontrib><creatorcontrib>SATO, YAYOI</creatorcontrib><creatorcontrib>SCHULER-METZ, ANNETTE</creatorcontrib><creatorcontrib>KONO, TAKESHI</creatorcontrib><creatorcontrib>SCHNAPP, ANDREAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANDSCHUH, SANDRA</au><au>FIEGEN, DENNIS</au><au>HOBBIE, SILKE</au><au>HOFFMANN, MATTHIAS</au><au>SATO, YAYOI</au><au>SCHULER-METZ, ANNETTE</au><au>KONO, TAKESHI</au><au>SCHNAPP, ANDREAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><date>2015-02-25</date><risdate>2015</risdate><abstract>The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | 4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE |
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