4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE

The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(eth...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HANDSCHUH, SANDRA, FIEGEN, DENNIS, HOBBIE, SILKE, HOFFMANN, MATTHIAS, SATO, YAYOI, SCHULER-METZ, ANNETTE, KONO, TAKESHI, SCHNAPP, ANDREAS
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator HANDSCHUH, SANDRA
FIEGEN, DENNIS
HOBBIE, SILKE
HOFFMANN, MATTHIAS
SATO, YAYOI
SCHULER-METZ, ANNETTE
KONO, TAKESHI
SCHNAPP, ANDREAS
description The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2313406B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2313406B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2313406B13</originalsourceid><addsrcrecordid>eNrjZPA20XXx9HUN8Yj0cfT19PMP8HD1i_RRCA51Cg7xDAkNcXVR8HMMCPEAKgjydPH0cw1WCPVzUQjxcPUMUggNdlVwDFbwdXXxdAZK8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeNcAI2NDYxMDMydDYyKUAAB03i2n</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><source>esp@cenet</source><creator>HANDSCHUH, SANDRA ; FIEGEN, DENNIS ; HOBBIE, SILKE ; HOFFMANN, MATTHIAS ; SATO, YAYOI ; SCHULER-METZ, ANNETTE ; KONO, TAKESHI ; SCHNAPP, ANDREAS</creator><creatorcontrib>HANDSCHUH, SANDRA ; FIEGEN, DENNIS ; HOBBIE, SILKE ; HOFFMANN, MATTHIAS ; SATO, YAYOI ; SCHULER-METZ, ANNETTE ; KONO, TAKESHI ; SCHNAPP, ANDREAS</creatorcontrib><description>The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150225&amp;DB=EPODOC&amp;CC=EP&amp;NR=2313406B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150225&amp;DB=EPODOC&amp;CC=EP&amp;NR=2313406B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANDSCHUH, SANDRA</creatorcontrib><creatorcontrib>FIEGEN, DENNIS</creatorcontrib><creatorcontrib>HOBBIE, SILKE</creatorcontrib><creatorcontrib>HOFFMANN, MATTHIAS</creatorcontrib><creatorcontrib>SATO, YAYOI</creatorcontrib><creatorcontrib>SCHULER-METZ, ANNETTE</creatorcontrib><creatorcontrib>KONO, TAKESHI</creatorcontrib><creatorcontrib>SCHNAPP, ANDREAS</creatorcontrib><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><description>The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPA20XXx9HUN8Yj0cfT19PMP8HD1i_RRCA51Cg7xDAkNcXVR8HMMCPEAKgjydPH0cw1WCPVzUQjxcPUMUggNdlVwDFbwdXXxdAZK8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeNcAI2NDYxMDMydDYyKUAAB03i2n</recordid><startdate>20150225</startdate><enddate>20150225</enddate><creator>HANDSCHUH, SANDRA</creator><creator>FIEGEN, DENNIS</creator><creator>HOBBIE, SILKE</creator><creator>HOFFMANN, MATTHIAS</creator><creator>SATO, YAYOI</creator><creator>SCHULER-METZ, ANNETTE</creator><creator>KONO, TAKESHI</creator><creator>SCHNAPP, ANDREAS</creator><scope>EVB</scope></search><sort><creationdate>20150225</creationdate><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><author>HANDSCHUH, SANDRA ; FIEGEN, DENNIS ; HOBBIE, SILKE ; HOFFMANN, MATTHIAS ; SATO, YAYOI ; SCHULER-METZ, ANNETTE ; KONO, TAKESHI ; SCHNAPP, ANDREAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2313406B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANDSCHUH, SANDRA</creatorcontrib><creatorcontrib>FIEGEN, DENNIS</creatorcontrib><creatorcontrib>HOBBIE, SILKE</creatorcontrib><creatorcontrib>HOFFMANN, MATTHIAS</creatorcontrib><creatorcontrib>SATO, YAYOI</creatorcontrib><creatorcontrib>SCHULER-METZ, ANNETTE</creatorcontrib><creatorcontrib>KONO, TAKESHI</creatorcontrib><creatorcontrib>SCHNAPP, ANDREAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANDSCHUH, SANDRA</au><au>FIEGEN, DENNIS</au><au>HOBBIE, SILKE</au><au>HOFFMANN, MATTHIAS</au><au>SATO, YAYOI</au><au>SCHULER-METZ, ANNETTE</au><au>KONO, TAKESHI</au><au>SCHNAPP, ANDREAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE</title><date>2015-02-25</date><risdate>2015</risdate><abstract>The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre ; ger
recordid cdi_epo_espacenet_EP2313406B1
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 4-DIMETHYLAMINOPHENYL SUBSTITUTED NAPTHTHYRIDINES UND THEIR USE AS MEDICINE
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T02%3A24%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=HANDSCHUH,%20SANDRA&rft.date=2015-02-25&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP2313406B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true