HSA-free formulations of interferon-beta

Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-²) and methods useful in their preparation are provided. The compositions comprise the IFN-² solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for...

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Bibliographische Detailangaben
Hauptverfasser: SHIRLEY, BRET, BABUKA, SUSAN, TELLERS, MELANIE, CHOE, MINNA
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-²) and methods useful in their preparation are provided. The compositions comprise the IFN-² solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-² in pharmaceutical compositions, are provided.