ANTIBODIES TO GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

ANTIBODIES TO GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

An isolated anti-GM-CSF antibody, comprising a V H region that has a CDR1 having a sequence NYYIH (SEQ ID NO:25), a CDR2 having a sequence WINAGNGNTKYSQKFQG (SEQ ID NO:27), and a CDR3 having a sequence RQRFPYYFDY (SEQ ID NO:16); and a V L region that has a CDR1 having a sequence RASQSVGTNVA (SEQ ID...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LUEHRSEN, Kenneth, YARRANTON, Geoffrey, T, BEBBINGTON, Christopher, R
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:An isolated anti-GM-CSF antibody, comprising a V H region that has a CDR1 having a sequence NYYIH (SEQ ID NO:25), a CDR2 having a sequence WINAGNGNTKYSQKFQG (SEQ ID NO:27), and a CDR3 having a sequence RQRFPYYFDY (SEQ ID NO:16); and a V L region that has a CDR1 having a sequence RASQSVGTNVA (SEQ ID NO:31) or RASQSIGSNLA (SEQ ID NO:32), a CDR2 having a sequence STSSRAT (SEQ ID NO:33), and a CDR3 having a sequence QQFNKSPLT (SEQ ID NO:18) or QQFNRSPLT (SEQ ID NO:28).