2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO[1,5-A]PYRIMIDINES AS ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF
The invention relates to substituted 2-alkylamino-3-(arylsulfonyl)cycloalkyl[e or d]pyrazolo[1,5-a]pyrimidines, to serotonin 5-HT 6 receptor antagonists, to novel drug substances and pharmaceutical compositions comprising the said compounds as active ingredients, and to novel medicaments and method...
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| creator | IVASHCHENKO, ALEXANDER VASILIEVICH SAVCHUK, NIKOLAY FILIPPOVICH IVASHCHENKO, ANDREY ALEXANDROVICH |
| description | The invention relates to substituted 2-alkylamino-3-(arylsulfonyl)cycloalkyl[e or d]pyrazolo[1,5-a]pyrimidines, to serotonin 5-HT 6 receptor antagonists, to novel drug substances and pharmaceutical compositions comprising the said compounds as active ingredients, and to novel medicaments and method for treatment and prophylaxis of various CNS diseases. 2-Alkylamino-3-arylsulfonylcycloalkyl[e]pyrazolo[1,5-a]pyrimidines of general formula 1 and 2-alkylamino-3-arylsulfonylcycloalkyl[d]pyrazolo[1,5-a]pyrimidines of general formula 2,
wherein: R 1 is hydrogen or C 1 -C 3 alkyl; R 2 is C 1 -C 3 alkyl; R 3 is hydrogen, one or more optionally identical halogen atoms, C 1 -C 3 alkyl or hydroxyl group optionally substituted with C 1 -C 3 alkyl; n is the whole numbers 1, 2 or 3. |
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wherein: R 1 is hydrogen or C 1 -C 3 alkyl; R 2 is C 1 -C 3 alkyl; R 3 is hydrogen, one or more optionally identical halogen atoms, C 1 -C 3 alkyl or hydroxyl group optionally substituted with C 1 -C 3 alkyl; n is the whole numbers 1, 2 or 3.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141022&DB=EPODOC&CC=EP&NR=2248816B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141022&DB=EPODOC&CC=EP&NR=2248816B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IVASHCHENKO, ALEXANDER VASILIEVICH</creatorcontrib><creatorcontrib>SAVCHUK, NIKOLAY FILIPPOVICH</creatorcontrib><creatorcontrib>IVASHCHENKO, ANDREY ALEXANDROVICH</creatorcontrib><title>2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO[1,5-A]PYRIMIDINES AS ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF</title><description>The invention relates to substituted 2-alkylamino-3-(arylsulfonyl)cycloalkyl[e or d]pyrazolo[1,5-a]pyrimidines, to serotonin 5-HT 6 receptor antagonists, to novel drug substances and pharmaceutical compositions comprising the said compounds as active ingredients, and to novel medicaments and method for treatment and prophylaxis of various CNS diseases. 2-Alkylamino-3-arylsulfonylcycloalkyl[e]pyrazolo[1,5-a]pyrimidines of general formula 1 and 2-alkylamino-3-arylsulfonylcycloalkyl[d]pyrazolo[1,5-a]pyrimidines of general formula 2,
wherein: R 1 is hydrogen or C 1 -C 3 alkyl; R 2 is C 1 -C 3 alkyl; R 3 is hydrogen, one or more optionally identical halogen atoms, C 1 -C 3 alkyl or hydroxyl group optionally substituted with C 1 -C 3 alkyl; n is the whole numbers 1, 2 or 3.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjMFqAjEURWfjotT-w_sAs5ixitvXzEsnmMkbkjeLKCKicSVV0H_qbzaWfkDhwuFeLuel-m4UunVy2FvPaq4wJBdHZ9gnp3TSjtFp9AzbDBzgtIMhBdyw4209WyjclWp721pPEbDEC36yt1EisIFIgaVUDwvVyRICaRqEQ5xBT9JxG8EUrXQEQ-B21GLZF0n7O42RngzEZlpNzofLPb_98bUCQ6I7lW_Xfb7fDsf8lR97GprmfbWqlx_1_B-XHzszRuA</recordid><startdate>20141022</startdate><enddate>20141022</enddate><creator>IVASHCHENKO, ALEXANDER VASILIEVICH</creator><creator>SAVCHUK, NIKOLAY FILIPPOVICH</creator><creator>IVASHCHENKO, ANDREY ALEXANDROVICH</creator><scope>EVB</scope></search><sort><creationdate>20141022</creationdate><title>2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO[1,5-A]PYRIMIDINES AS ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF</title><author>IVASHCHENKO, ALEXANDER VASILIEVICH ; SAVCHUK, NIKOLAY FILIPPOVICH ; IVASHCHENKO, ANDREY ALEXANDROVICH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2248816B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>IVASHCHENKO, ALEXANDER VASILIEVICH</creatorcontrib><creatorcontrib>SAVCHUK, NIKOLAY FILIPPOVICH</creatorcontrib><creatorcontrib>IVASHCHENKO, ANDREY ALEXANDROVICH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IVASHCHENKO, ALEXANDER VASILIEVICH</au><au>SAVCHUK, NIKOLAY FILIPPOVICH</au><au>IVASHCHENKO, ANDREY ALEXANDROVICH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO[1,5-A]PYRIMIDINES AS ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF</title><date>2014-10-22</date><risdate>2014</risdate><abstract>The invention relates to substituted 2-alkylamino-3-(arylsulfonyl)cycloalkyl[e or d]pyrazolo[1,5-a]pyrimidines, to serotonin 5-HT 6 receptor antagonists, to novel drug substances and pharmaceutical compositions comprising the said compounds as active ingredients, and to novel medicaments and method for treatment and prophylaxis of various CNS diseases. 2-Alkylamino-3-arylsulfonylcycloalkyl[e]pyrazolo[1,5-a]pyrimidines of general formula 1 and 2-alkylamino-3-arylsulfonylcycloalkyl[d]pyrazolo[1,5-a]pyrimidines of general formula 2,
wherein: R 1 is hydrogen or C 1 -C 3 alkyl; R 2 is C 1 -C 3 alkyl; R 3 is hydrogen, one or more optionally identical halogen atoms, C 1 -C 3 alkyl or hydroxyl group optionally substituted with C 1 -C 3 alkyl; n is the whole numbers 1, 2 or 3.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO[1,5-A]PYRIMIDINES AS ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF |
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