CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190
DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiy...
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| creator | HOVLAND, RAGNAR NOESKE, ALEXANDER, TOBIAS BARLIND, JONAS, GUNNAR JOHANNESSON, PETRA JOHANSSON, JAN, MAGNUS BIRCH, ALAN, MARTIN BUTLIN, ROGER, JOHN LEACH, ANDREW PETERSSON, ANNIKA, ULRIKA GREEN, CLIVE BAUER, UDO, ANDREAS |
| description | DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2234978A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2234978A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2234978A13</originalsourceid><addsrcrecordid>eNrjZNB2dgxycvT1j_RRcPb3DfAP9XMJVnAMVnBxdwwxVPD08_B08gzxDwpWMLQ04GFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BRkbGJpbmFo6GxkQoAQAKLiQs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><source>esp@cenet</source><creator>HOVLAND, RAGNAR ; NOESKE, ALEXANDER, TOBIAS ; BARLIND, JONAS, GUNNAR ; JOHANNESSON, PETRA ; JOHANSSON, JAN, MAGNUS ; BIRCH, ALAN, MARTIN ; BUTLIN, ROGER, JOHN ; LEACH, ANDREW ; PETERSSON, ANNIKA, ULRIKA ; GREEN, CLIVE ; BAUER, UDO, ANDREAS</creator><creatorcontrib>HOVLAND, RAGNAR ; NOESKE, ALEXANDER, TOBIAS ; BARLIND, JONAS, GUNNAR ; JOHANNESSON, PETRA ; JOHANSSON, JAN, MAGNUS ; BIRCH, ALAN, MARTIN ; BUTLIN, ROGER, JOHN ; LEACH, ANDREW ; PETERSSON, ANNIKA, ULRIKA ; GREEN, CLIVE ; BAUER, UDO, ANDREAS</creatorcontrib><description>DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101006&DB=EPODOC&CC=EP&NR=2234978A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101006&DB=EPODOC&CC=EP&NR=2234978A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HOVLAND, RAGNAR</creatorcontrib><creatorcontrib>NOESKE, ALEXANDER, TOBIAS</creatorcontrib><creatorcontrib>BARLIND, JONAS, GUNNAR</creatorcontrib><creatorcontrib>JOHANNESSON, PETRA</creatorcontrib><creatorcontrib>JOHANSSON, JAN, MAGNUS</creatorcontrib><creatorcontrib>BIRCH, ALAN, MARTIN</creatorcontrib><creatorcontrib>BUTLIN, ROGER, JOHN</creatorcontrib><creatorcontrib>LEACH, ANDREW</creatorcontrib><creatorcontrib>PETERSSON, ANNIKA, ULRIKA</creatorcontrib><creatorcontrib>GREEN, CLIVE</creatorcontrib><creatorcontrib>BAUER, UDO, ANDREAS</creatorcontrib><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><description>DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB2dgxycvT1j_RRcPb3DfAP9XMJVnAMVnBxdwwxVPD08_B08gzxDwpWMLQ04GFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BRkbGJpbmFo6GxkQoAQAKLiQs</recordid><startdate>20101006</startdate><enddate>20101006</enddate><creator>HOVLAND, RAGNAR</creator><creator>NOESKE, ALEXANDER, TOBIAS</creator><creator>BARLIND, JONAS, GUNNAR</creator><creator>JOHANNESSON, PETRA</creator><creator>JOHANSSON, JAN, MAGNUS</creator><creator>BIRCH, ALAN, MARTIN</creator><creator>BUTLIN, ROGER, JOHN</creator><creator>LEACH, ANDREW</creator><creator>PETERSSON, ANNIKA, ULRIKA</creator><creator>GREEN, CLIVE</creator><creator>BAUER, UDO, ANDREAS</creator><scope>EVB</scope></search><sort><creationdate>20101006</creationdate><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><author>HOVLAND, RAGNAR ; NOESKE, ALEXANDER, TOBIAS ; BARLIND, JONAS, GUNNAR ; JOHANNESSON, PETRA ; JOHANSSON, JAN, MAGNUS ; BIRCH, ALAN, MARTIN ; BUTLIN, ROGER, JOHN ; LEACH, ANDREW ; PETERSSON, ANNIKA, ULRIKA ; GREEN, CLIVE ; BAUER, UDO, ANDREAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2234978A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HOVLAND, RAGNAR</creatorcontrib><creatorcontrib>NOESKE, ALEXANDER, TOBIAS</creatorcontrib><creatorcontrib>BARLIND, JONAS, GUNNAR</creatorcontrib><creatorcontrib>JOHANNESSON, PETRA</creatorcontrib><creatorcontrib>JOHANSSON, JAN, MAGNUS</creatorcontrib><creatorcontrib>BIRCH, ALAN, MARTIN</creatorcontrib><creatorcontrib>BUTLIN, ROGER, JOHN</creatorcontrib><creatorcontrib>LEACH, ANDREW</creatorcontrib><creatorcontrib>PETERSSON, ANNIKA, ULRIKA</creatorcontrib><creatorcontrib>GREEN, CLIVE</creatorcontrib><creatorcontrib>BAUER, UDO, ANDREAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HOVLAND, RAGNAR</au><au>NOESKE, ALEXANDER, TOBIAS</au><au>BARLIND, JONAS, GUNNAR</au><au>JOHANNESSON, PETRA</au><au>JOHANSSON, JAN, MAGNUS</au><au>BIRCH, ALAN, MARTIN</au><au>BUTLIN, ROGER, JOHN</au><au>LEACH, ANDREW</au><au>PETERSSON, ANNIKA, ULRIKA</au><au>GREEN, CLIVE</au><au>BAUER, UDO, ANDREAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190</title><date>2010-10-06</date><risdate>2010</risdate><abstract>DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is 0; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH2)r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190 |
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