PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE
The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogs thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | OESTERGAARD, SOEREN KRUSE, THOMAS SCHAEFFER, LAUGE SPETZLER, JANE GARIBAY, PATRICK WILLIAM LAU, JESPER THOEGERSEN, HENNING RUNGE, STEFFEN |
| description | The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogs thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2190460A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2190460A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2190460A13</originalsourceid><addsrcrecordid>eNrjZLALcA0I8XRxDVZwcQ3yDHMM8YxydVEI9wzxUHDUddJ11nXRVXD0c1EI8XD1DAKRQY4BrqEhns6OPgqhwa48DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeNcDI0NLAxMzA0dCYCCUA0WQpMw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE</title><source>esp@cenet</source><creator>OESTERGAARD, SOEREN ; KRUSE, THOMAS ; SCHAEFFER, LAUGE ; SPETZLER, JANE ; GARIBAY, PATRICK WILLIAM ; LAU, JESPER ; THOEGERSEN, HENNING ; RUNGE, STEFFEN</creator><creatorcontrib>OESTERGAARD, SOEREN ; KRUSE, THOMAS ; SCHAEFFER, LAUGE ; SPETZLER, JANE ; GARIBAY, PATRICK WILLIAM ; LAU, JESPER ; THOEGERSEN, HENNING ; RUNGE, STEFFEN</creatorcontrib><description>The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogs thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100602&DB=EPODOC&CC=EP&NR=2190460A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100602&DB=EPODOC&CC=EP&NR=2190460A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OESTERGAARD, SOEREN</creatorcontrib><creatorcontrib>KRUSE, THOMAS</creatorcontrib><creatorcontrib>SCHAEFFER, LAUGE</creatorcontrib><creatorcontrib>SPETZLER, JANE</creatorcontrib><creatorcontrib>GARIBAY, PATRICK WILLIAM</creatorcontrib><creatorcontrib>LAU, JESPER</creatorcontrib><creatorcontrib>THOEGERSEN, HENNING</creatorcontrib><creatorcontrib>RUNGE, STEFFEN</creatorcontrib><title>PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE</title><description>The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogs thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLALcA0I8XRxDVZwcQ3yDHMM8YxydVEI9wzxUHDUddJ11nXRVXD0c1EI8XD1DAKRQY4BrqEhns6OPgqhwa48DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeNcDI0NLAxMzA0dCYCCUA0WQpMw</recordid><startdate>20100602</startdate><enddate>20100602</enddate><creator>OESTERGAARD, SOEREN</creator><creator>KRUSE, THOMAS</creator><creator>SCHAEFFER, LAUGE</creator><creator>SPETZLER, JANE</creator><creator>GARIBAY, PATRICK WILLIAM</creator><creator>LAU, JESPER</creator><creator>THOEGERSEN, HENNING</creator><creator>RUNGE, STEFFEN</creator><scope>EVB</scope></search><sort><creationdate>20100602</creationdate><title>PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE</title><author>OESTERGAARD, SOEREN ; KRUSE, THOMAS ; SCHAEFFER, LAUGE ; SPETZLER, JANE ; GARIBAY, PATRICK WILLIAM ; LAU, JESPER ; THOEGERSEN, HENNING ; RUNGE, STEFFEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2190460A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>OESTERGAARD, SOEREN</creatorcontrib><creatorcontrib>KRUSE, THOMAS</creatorcontrib><creatorcontrib>SCHAEFFER, LAUGE</creatorcontrib><creatorcontrib>SPETZLER, JANE</creatorcontrib><creatorcontrib>GARIBAY, PATRICK WILLIAM</creatorcontrib><creatorcontrib>LAU, JESPER</creatorcontrib><creatorcontrib>THOEGERSEN, HENNING</creatorcontrib><creatorcontrib>RUNGE, STEFFEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OESTERGAARD, SOEREN</au><au>KRUSE, THOMAS</au><au>SCHAEFFER, LAUGE</au><au>SPETZLER, JANE</au><au>GARIBAY, PATRICK WILLIAM</au><au>LAU, JESPER</au><au>THOEGERSEN, HENNING</au><au>RUNGE, STEFFEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE</title><date>2010-06-02</date><risdate>2010</risdate><abstract>The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogs thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP2190460A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T11%3A56%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=OESTERGAARD,%20SOEREN&rft.date=2010-06-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP2190460A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |