Specific binding proteins and uses thereof
The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the inven...
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| creator | RENNER, CHRISTOPH NICE, EDOUARD, COLLINS JOHNS, TERRANCE, GRANT RITTER, GERD BURGESS, ANTHONY, WILKS OLD, LLOYD, J HUANG, HUEI-JEN PANOUSIS, CON CAVENEE, WEBSTER, K STOCKERT, ELISABETH COLLINS, PETER SCOTT, ANDREW, MARK JUNGBLUTH, ACHIM |
| description | The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptids. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. |
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The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptids. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100317&DB=EPODOC&CC=EP&NR=2163256A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100317&DB=EPODOC&CC=EP&NR=2163256A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RENNER, CHRISTOPH</creatorcontrib><creatorcontrib>NICE, EDOUARD, COLLINS</creatorcontrib><creatorcontrib>JOHNS, TERRANCE, GRANT</creatorcontrib><creatorcontrib>RITTER, GERD</creatorcontrib><creatorcontrib>BURGESS, ANTHONY, WILKS</creatorcontrib><creatorcontrib>OLD, LLOYD, J</creatorcontrib><creatorcontrib>HUANG, HUEI-JEN</creatorcontrib><creatorcontrib>PANOUSIS, CON</creatorcontrib><creatorcontrib>CAVENEE, WEBSTER, K</creatorcontrib><creatorcontrib>STOCKERT, ELISABETH</creatorcontrib><creatorcontrib>COLLINS, PETER</creatorcontrib><creatorcontrib>SCOTT, ANDREW, MARK</creatorcontrib><creatorcontrib>JUNGBLUTH, ACHIM</creatorcontrib><title>Specific binding proteins and uses thereof</title><description>The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptids. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAKLkhNzkzLTFZIysxLycxLVygoyi9JzcwrVkjMS1EoLU4tVijJSC1KzU_jYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgFGhmbGRqZmjobGRCgBAOFLKKA</recordid><startdate>20100317</startdate><enddate>20100317</enddate><creator>RENNER, CHRISTOPH</creator><creator>NICE, EDOUARD, COLLINS</creator><creator>JOHNS, TERRANCE, GRANT</creator><creator>RITTER, GERD</creator><creator>BURGESS, ANTHONY, WILKS</creator><creator>OLD, LLOYD, J</creator><creator>HUANG, HUEI-JEN</creator><creator>PANOUSIS, CON</creator><creator>CAVENEE, WEBSTER, K</creator><creator>STOCKERT, ELISABETH</creator><creator>COLLINS, PETER</creator><creator>SCOTT, ANDREW, MARK</creator><creator>JUNGBLUTH, ACHIM</creator><scope>EVB</scope></search><sort><creationdate>20100317</creationdate><title>Specific binding proteins and uses thereof</title><author>RENNER, CHRISTOPH ; 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The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptids. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Specific binding proteins and uses thereof |
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