Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies
The invention discloses a novel bioreactor apparatus integrated in a culture system which may be used in cell seeding, expansion and differentiation under highly controlled and monitored conditions. The bioreactor apparatus (1) is a multichamber perfusion device featuring an innovative construct ret...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | COSTA, PEDRO FERREIRA DA REIS, RUI LUIS GONCALVES DOS MARTINS, ALBINO MANUEL PEREIRA NEVES, NUNO JOAO MELEIRO ALVES DAS GOMES, MARIA MANUELA ESTIMA |
| description | The invention discloses a novel bioreactor apparatus integrated in a culture system which may be used in cell seeding, expansion and differentiation under highly controlled and monitored conditions. The bioreactor apparatus (1) is a multichamber perfusion device featuring an innovative construct retention mechanism and a medium flow distribution chamber. When integrated in the bioreactor system herein described, the bioreactor apparatus can be utilized for enhancing and directing cellular growth and differentiation by establishing a dynamic culture environment. It is capable of homogenously and simultaneously exposing several two- or three-dimensional cell/tissue constructs to shear stress through the perfusion of culture medium which may be perfused uni- or bi-directionally. The culture system is self-contained, being independent and self-sufficient concerning the establishment of its inner temperature and medium gaseous composition. The system also integrates devices for continuous monitoring and control of culture parameters, and quantification of various biochemical compounds dissolved in the perfused culture medium. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2151491A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2151491A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2151491A23</originalsourceid><addsrcrecordid>eNqNjLEKwkAQRNNYiPoP-wMWiVpYikRsBAv7cLlM4kJyF3b3EP_eE_wAq3kD82ZZpFsajf3TTS2EWo4C5y0KvdieuXcs8MYxuJFmSJ80M3EwDOIMXUZy5PNJEpC-1TBRn31j1QRCGDgAwmEgta8yMHRdLHo3Kja_XBV0qR_n6xZzbKCz8wiwpr5X5aHcH8tTtftj8gEfKkY9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies</title><source>esp@cenet</source><creator>COSTA, PEDRO FERREIRA DA ; REIS, RUI LUIS GONCALVES DOS ; MARTINS, ALBINO MANUEL PEREIRA ; NEVES, NUNO JOAO MELEIRO ALVES DAS ; GOMES, MARIA MANUELA ESTIMA</creator><creatorcontrib>COSTA, PEDRO FERREIRA DA ; REIS, RUI LUIS GONCALVES DOS ; MARTINS, ALBINO MANUEL PEREIRA ; NEVES, NUNO JOAO MELEIRO ALVES DAS ; GOMES, MARIA MANUELA ESTIMA</creatorcontrib><description>The invention discloses a novel bioreactor apparatus integrated in a culture system which may be used in cell seeding, expansion and differentiation under highly controlled and monitored conditions. The bioreactor apparatus (1) is a multichamber perfusion device featuring an innovative construct retention mechanism and a medium flow distribution chamber. When integrated in the bioreactor system herein described, the bioreactor apparatus can be utilized for enhancing and directing cellular growth and differentiation by establishing a dynamic culture environment. It is capable of homogenously and simultaneously exposing several two- or three-dimensional cell/tissue constructs to shear stress through the perfusion of culture medium which may be perfused uni- or bi-directionally. The culture system is self-contained, being independent and self-sufficient concerning the establishment of its inner temperature and medium gaseous composition. The system also integrates devices for continuous monitoring and control of culture parameters, and quantification of various biochemical compounds dissolved in the perfused culture medium.</description><language>eng ; fre ; ger</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; BEER ; BIOCHEMISTRY ; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ; CHEMISTRY ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; SPIRITS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100210&DB=EPODOC&CC=EP&NR=2151491A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100210&DB=EPODOC&CC=EP&NR=2151491A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>COSTA, PEDRO FERREIRA DA</creatorcontrib><creatorcontrib>REIS, RUI LUIS GONCALVES DOS</creatorcontrib><creatorcontrib>MARTINS, ALBINO MANUEL PEREIRA</creatorcontrib><creatorcontrib>NEVES, NUNO JOAO MELEIRO ALVES DAS</creatorcontrib><creatorcontrib>GOMES, MARIA MANUELA ESTIMA</creatorcontrib><title>Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies</title><description>The invention discloses a novel bioreactor apparatus integrated in a culture system which may be used in cell seeding, expansion and differentiation under highly controlled and monitored conditions. The bioreactor apparatus (1) is a multichamber perfusion device featuring an innovative construct retention mechanism and a medium flow distribution chamber. When integrated in the bioreactor system herein described, the bioreactor apparatus can be utilized for enhancing and directing cellular growth and differentiation by establishing a dynamic culture environment. It is capable of homogenously and simultaneously exposing several two- or three-dimensional cell/tissue constructs to shear stress through the perfusion of culture medium which may be perfused uni- or bi-directionally. The culture system is self-contained, being independent and self-sufficient concerning the establishment of its inner temperature and medium gaseous composition. The system also integrates devices for continuous monitoring and control of culture parameters, and quantification of various biochemical compounds dissolved in the perfused culture medium.</description><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>SPIRITS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwkAQRNNYiPoP-wMWiVpYikRsBAv7cLlM4kJyF3b3EP_eE_wAq3kD82ZZpFsajf3TTS2EWo4C5y0KvdieuXcs8MYxuJFmSJ80M3EwDOIMXUZy5PNJEpC-1TBRn31j1QRCGDgAwmEgta8yMHRdLHo3Kja_XBV0qR_n6xZzbKCz8wiwpr5X5aHcH8tTtftj8gEfKkY9</recordid><startdate>20100210</startdate><enddate>20100210</enddate><creator>COSTA, PEDRO FERREIRA DA</creator><creator>REIS, RUI LUIS GONCALVES DOS</creator><creator>MARTINS, ALBINO MANUEL PEREIRA</creator><creator>NEVES, NUNO JOAO MELEIRO ALVES DAS</creator><creator>GOMES, MARIA MANUELA ESTIMA</creator><scope>EVB</scope></search><sort><creationdate>20100210</creationdate><title>Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies</title><author>COSTA, PEDRO FERREIRA DA ; REIS, RUI LUIS GONCALVES DOS ; MARTINS, ALBINO MANUEL PEREIRA ; NEVES, NUNO JOAO MELEIRO ALVES DAS ; GOMES, MARIA MANUELA ESTIMA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2151491A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2010</creationdate><topic>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>SPIRITS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>COSTA, PEDRO FERREIRA DA</creatorcontrib><creatorcontrib>REIS, RUI LUIS GONCALVES DOS</creatorcontrib><creatorcontrib>MARTINS, ALBINO MANUEL PEREIRA</creatorcontrib><creatorcontrib>NEVES, NUNO JOAO MELEIRO ALVES DAS</creatorcontrib><creatorcontrib>GOMES, MARIA MANUELA ESTIMA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>COSTA, PEDRO FERREIRA DA</au><au>REIS, RUI LUIS GONCALVES DOS</au><au>MARTINS, ALBINO MANUEL PEREIRA</au><au>NEVES, NUNO JOAO MELEIRO ALVES DAS</au><au>GOMES, MARIA MANUELA ESTIMA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies</title><date>2010-02-10</date><risdate>2010</risdate><abstract>The invention discloses a novel bioreactor apparatus integrated in a culture system which may be used in cell seeding, expansion and differentiation under highly controlled and monitored conditions. The bioreactor apparatus (1) is a multichamber perfusion device featuring an innovative construct retention mechanism and a medium flow distribution chamber. When integrated in the bioreactor system herein described, the bioreactor apparatus can be utilized for enhancing and directing cellular growth and differentiation by establishing a dynamic culture environment. It is capable of homogenously and simultaneously exposing several two- or three-dimensional cell/tissue constructs to shear stress through the perfusion of culture medium which may be perfused uni- or bi-directionally. The culture system is self-contained, being independent and self-sufficient concerning the establishment of its inner temperature and medium gaseous composition. The system also integrates devices for continuous monitoring and control of culture parameters, and quantification of various biochemical compounds dissolved in the perfused culture medium.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP2151491A2 |
| source | esp@cenet |
| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY ENZYMOLOGY METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SPIRITS TRANSPORTING VINEGAR WINE |
| title | Multichamber bioreactor with bidirectional perfusion integrated in a culture system for tissue engineering strategies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T14%3A02%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=COSTA,%20PEDRO%20FERREIRA%20DA&rft.date=2010-02-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP2151491A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |