QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS

QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS

Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 act...

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Bibliographische Detailangaben
Hauptverfasser: MATHER, OWEN CLIFFORD, WHITTAKER, MARK, HESTERKAMP, THOMAS, MONTALBETTI, CHRISTIAN ALDO GEORGES NAPOLEON, COURTNEY, STEPHEN MARTIN, YARNOLD, CHRISTOPHER JOHN, BARKER, OLIVER ROBIN, GARDINER, MIHALY DANIEL
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.