PIG MODEL FOR PSORIASIS
The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene,...
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| creator | KRAGH, PETER MICHAEL KRISTIANSEN, KARSTEN PETERSEN, THOMAS KONGSTAD MIKKELSEN, JACOB GIEHM BOLUND, LARS AXEL STAUNSTRUP, NICKLAS HEINE SVENSSON, LARS SOERENSEN, CHARLOTTE BRANDT |
| description | The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, l B-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunB ec-Jun ep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2132321A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2132321A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2132321A13</originalsourceid><addsrcrecordid>eNrjZBAP8HRX8PV3cfVRcPMPUggI9g_ydAz2DOZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAUaGxkbGRoaOhsZEKAEAi9Ye1w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PIG MODEL FOR PSORIASIS</title><source>esp@cenet</source><creator>KRAGH, PETER MICHAEL ; KRISTIANSEN, KARSTEN ; PETERSEN, THOMAS KONGSTAD ; MIKKELSEN, JACOB GIEHM ; BOLUND, LARS AXEL ; STAUNSTRUP, NICKLAS HEINE ; SVENSSON, LARS ; SOERENSEN, CHARLOTTE BRANDT</creator><creatorcontrib>KRAGH, PETER MICHAEL ; KRISTIANSEN, KARSTEN ; PETERSEN, THOMAS KONGSTAD ; MIKKELSEN, JACOB GIEHM ; BOLUND, LARS AXEL ; STAUNSTRUP, NICKLAS HEINE ; SVENSSON, LARS ; SOERENSEN, CHARLOTTE BRANDT</creatorcontrib><description>The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, l B-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunB ec-Jun ep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed.</description><language>eng ; fre ; ger</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NEW BREEDS OF ANIMALS ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; SPIRITS ; TESTING ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091216&DB=EPODOC&CC=EP&NR=2132321A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091216&DB=EPODOC&CC=EP&NR=2132321A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KRAGH, PETER MICHAEL</creatorcontrib><creatorcontrib>KRISTIANSEN, KARSTEN</creatorcontrib><creatorcontrib>PETERSEN, THOMAS KONGSTAD</creatorcontrib><creatorcontrib>MIKKELSEN, JACOB GIEHM</creatorcontrib><creatorcontrib>BOLUND, LARS AXEL</creatorcontrib><creatorcontrib>STAUNSTRUP, NICKLAS HEINE</creatorcontrib><creatorcontrib>SVENSSON, LARS</creatorcontrib><creatorcontrib>SOERENSEN, CHARLOTTE BRANDT</creatorcontrib><title>PIG MODEL FOR PSORIASIS</title><description>The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, l B-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunB ec-Jun ep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAP8HRX8PV3cfVRcPMPUggI9g_ydAz2DOZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAUaGxkbGRoaOhsZEKAEAi9Ye1w</recordid><startdate>20091216</startdate><enddate>20091216</enddate><creator>KRAGH, PETER MICHAEL</creator><creator>KRISTIANSEN, KARSTEN</creator><creator>PETERSEN, THOMAS KONGSTAD</creator><creator>MIKKELSEN, JACOB GIEHM</creator><creator>BOLUND, LARS AXEL</creator><creator>STAUNSTRUP, NICKLAS HEINE</creator><creator>SVENSSON, LARS</creator><creator>SOERENSEN, CHARLOTTE BRANDT</creator><scope>EVB</scope></search><sort><creationdate>20091216</creationdate><title>PIG MODEL FOR PSORIASIS</title><author>KRAGH, PETER MICHAEL ; KRISTIANSEN, KARSTEN ; PETERSEN, THOMAS KONGSTAD ; MIKKELSEN, JACOB GIEHM ; BOLUND, LARS AXEL ; STAUNSTRUP, NICKLAS HEINE ; SVENSSON, LARS ; SOERENSEN, CHARLOTTE BRANDT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2132321A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2009</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KRAGH, PETER MICHAEL</creatorcontrib><creatorcontrib>KRISTIANSEN, KARSTEN</creatorcontrib><creatorcontrib>PETERSEN, THOMAS KONGSTAD</creatorcontrib><creatorcontrib>MIKKELSEN, JACOB GIEHM</creatorcontrib><creatorcontrib>BOLUND, LARS AXEL</creatorcontrib><creatorcontrib>STAUNSTRUP, NICKLAS HEINE</creatorcontrib><creatorcontrib>SVENSSON, LARS</creatorcontrib><creatorcontrib>SOERENSEN, CHARLOTTE BRANDT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KRAGH, PETER MICHAEL</au><au>KRISTIANSEN, KARSTEN</au><au>PETERSEN, THOMAS KONGSTAD</au><au>MIKKELSEN, JACOB GIEHM</au><au>BOLUND, LARS AXEL</au><au>STAUNSTRUP, NICKLAS HEINE</au><au>SVENSSON, LARS</au><au>SOERENSEN, CHARLOTTE BRANDT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PIG MODEL FOR PSORIASIS</title><date>2009-12-16</date><risdate>2009</risdate><abstract>The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, l B-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunB ec-Jun ep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE |
| title | PIG MODEL FOR PSORIASIS |
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