PROCESS FOR THE PREPARATION OF ABACAVIR

Process for the preparation of abacavir starting from compound of formula (IV) where R 1 is a (C 1 -C 4 )-alkyl radical comprising first reacting said compound (IV) with anhydrous hydrochloric acid/(C 1 -C 6 )-alcohol, and then with tri(C 1 -C 4 )-alkyl orthoformate, in the absence of water, followe...

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Hauptverfasser:	BERENGUER MAIMO, RAMON, ELIAS RIUS, LAIA, MEDRANO RUPEREZ, JORGE, CAMPON PARDO, JULIO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	BERENGUER MAIMO, RAMON ELIAS RIUS, LAIA MEDRANO RUPEREZ, JORGE CAMPON PARDO, JULIO
description	Process for the preparation of abacavir starting from compound of formula (IV) where R 1 is a (C 1 -C 4 )-alkyl radical comprising first reacting said compound (IV) with anhydrous hydrochloric acid/(C 1 -C 6 )-alcohol, and then with tri(C 1 -C 4 )-alkyl orthoformate, in the absence of water, followed by reacting the compound obtained with cyclopropylamine and hydrolysing the compound obtained to yield abacavir or its salts.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	PROCESS FOR THE PREPARATION OF ABACAVIR
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