Esters of glucuronide prodrugs of anthracyclines and method of preparation and use in tumor-selective chemotherapy

The invention relates to novel esters and in particular to some novel esters of glucuronide prodrugs of anthracyclines having tunable water-solubility, their synthesis and use in tumor-selective chemotherapy. It appeared that in the final step in the synthesis of these prodrugs, i.e. the coupling of...

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Hauptverfasser: HAISMA, HIDDE JACOB, DE VOS, DICK, SCHEEREN, JOHAN WILHELM, CORNELISSEN, JEROEN JOHANNES LAMBERTUS MARIA, ABEN, RENE WILHELMUS MARIE
Format: Patent
Sprache:eng ; fre ; ger
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