Therapeutic use of nucleic acid micropheres

An aqueous process for producing biologically active microspheres comprising nucleic acids, the process comprising (a) dissolving the nucleic acids with an aqueous solvent to form an aqueous composition, wherein at least one water soluble polymer is added to the aqueous solvent, and (b) forming micr...

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Bibliographische Detailangaben
Hauptverfasser: BROWN, LARRY, R, SCOTT, TERENCE, L, LAFRENIERE, DEBRA, BISKER-LEIB, VERED
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:An aqueous process for producing biologically active microspheres comprising nucleic acids, the process comprising (a) dissolving the nucleic acids with an aqueous solvent to form an aqueous composition, wherein at least one water soluble polymer is added to the aqueous solvent, and (b) forming microspheres comprising nucleic acids, said microspheres having an average particle size of not greater than about 50 microns and being substantially free of said polymer.