Differentially Expressed Tumour-specific Polypeptides for use in the Diagnosis and Treatment of Cancer
The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin-like protein (SYPL), stomatin-like 2 (STOML2), Ras-...
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| creator | LAMER, STEPHANIE ROTHMANN-COSIC, KIRSTEN SEIBERT, VOLKER LEHNHERR-ILIANIA, TATIANA FOTIADIS, NIKOLETA-KYRIAKI HEIM, STEFFEN STEDRONSKY, KATRIN BUSCHMANN, THOMAS FUCHS, MIRIAM MEUER, JOERN PEREZ, SILVIA TORTOLA |
| description | The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin-like protein (SYPL), stomatin-like 2 (STOML2), Ras-related GTP-binding protein RAGA), nucleotide-sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2050827A3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2050827A3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2050827A33</originalsourceid><addsrcrecordid>eNqNjLEOgkAQBWksjPoP-wMkBGK0NYCxtKAnl-OtbnLcXW6PRP5eCj_AapqZ2RfcCTMSfBbj3Er9JyaoYqJhmcOSSo2wwmLpGdwaEbNMUOKQaFGQeMpvUCfm5YOKkvFbmWDyvC0pMLXGW6RjsWPjFKcfDwXd-6F9lIhhhEZj4ZHH_llX5-paX25N84fyBRQ0PyQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Differentially Expressed Tumour-specific Polypeptides for use in the Diagnosis and Treatment of Cancer</title><source>esp@cenet</source><creator>LAMER, STEPHANIE ; ROTHMANN-COSIC, KIRSTEN ; SEIBERT, VOLKER ; LEHNHERR-ILIANIA, TATIANA ; FOTIADIS, NIKOLETA-KYRIAKI ; HEIM, STEFFEN ; STEDRONSKY, KATRIN ; BUSCHMANN, THOMAS ; FUCHS, MIRIAM ; MEUER, JOERN ; PEREZ, SILVIA TORTOLA</creator><creatorcontrib>LAMER, STEPHANIE ; ROTHMANN-COSIC, KIRSTEN ; SEIBERT, VOLKER ; LEHNHERR-ILIANIA, TATIANA ; FOTIADIS, NIKOLETA-KYRIAKI ; HEIM, STEFFEN ; STEDRONSKY, KATRIN ; BUSCHMANN, THOMAS ; FUCHS, MIRIAM ; MEUER, JOERN ; PEREZ, SILVIA TORTOLA</creatorcontrib><description>The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin-like protein (SYPL), stomatin-like 2 (STOML2), Ras-related GTP-binding protein RAGA), nucleotide-sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090902&DB=EPODOC&CC=EP&NR=2050827A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090902&DB=EPODOC&CC=EP&NR=2050827A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAMER, STEPHANIE</creatorcontrib><creatorcontrib>ROTHMANN-COSIC, KIRSTEN</creatorcontrib><creatorcontrib>SEIBERT, VOLKER</creatorcontrib><creatorcontrib>LEHNHERR-ILIANIA, TATIANA</creatorcontrib><creatorcontrib>FOTIADIS, NIKOLETA-KYRIAKI</creatorcontrib><creatorcontrib>HEIM, STEFFEN</creatorcontrib><creatorcontrib>STEDRONSKY, KATRIN</creatorcontrib><creatorcontrib>BUSCHMANN, THOMAS</creatorcontrib><creatorcontrib>FUCHS, MIRIAM</creatorcontrib><creatorcontrib>MEUER, JOERN</creatorcontrib><creatorcontrib>PEREZ, SILVIA TORTOLA</creatorcontrib><title>Differentially Expressed Tumour-specific Polypeptides for use in the Diagnosis and Treatment of Cancer</title><description>The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin-like protein (SYPL), stomatin-like 2 (STOML2), Ras-related GTP-binding protein RAGA), nucleotide-sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEOgkAQBWksjPoP-wMkBGK0NYCxtKAnl-OtbnLcXW6PRP5eCj_AapqZ2RfcCTMSfBbj3Er9JyaoYqJhmcOSSo2wwmLpGdwaEbNMUOKQaFGQeMpvUCfm5YOKkvFbmWDyvC0pMLXGW6RjsWPjFKcfDwXd-6F9lIhhhEZj4ZHH_llX5-paX25N84fyBRQ0PyQ</recordid><startdate>20090902</startdate><enddate>20090902</enddate><creator>LAMER, STEPHANIE</creator><creator>ROTHMANN-COSIC, KIRSTEN</creator><creator>SEIBERT, VOLKER</creator><creator>LEHNHERR-ILIANIA, TATIANA</creator><creator>FOTIADIS, NIKOLETA-KYRIAKI</creator><creator>HEIM, STEFFEN</creator><creator>STEDRONSKY, KATRIN</creator><creator>BUSCHMANN, THOMAS</creator><creator>FUCHS, MIRIAM</creator><creator>MEUER, JOERN</creator><creator>PEREZ, SILVIA TORTOLA</creator><scope>EVB</scope></search><sort><creationdate>20090902</creationdate><title>Differentially Expressed Tumour-specific Polypeptides for use in the Diagnosis and Treatment of Cancer</title><author>LAMER, STEPHANIE ; ROTHMANN-COSIC, KIRSTEN ; SEIBERT, VOLKER ; LEHNHERR-ILIANIA, TATIANA ; FOTIADIS, NIKOLETA-KYRIAKI ; HEIM, STEFFEN ; STEDRONSKY, KATRIN ; BUSCHMANN, THOMAS ; FUCHS, MIRIAM ; MEUER, JOERN ; PEREZ, SILVIA TORTOLA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2050827A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2009</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LAMER, STEPHANIE</creatorcontrib><creatorcontrib>ROTHMANN-COSIC, KIRSTEN</creatorcontrib><creatorcontrib>SEIBERT, VOLKER</creatorcontrib><creatorcontrib>LEHNHERR-ILIANIA, TATIANA</creatorcontrib><creatorcontrib>FOTIADIS, NIKOLETA-KYRIAKI</creatorcontrib><creatorcontrib>HEIM, STEFFEN</creatorcontrib><creatorcontrib>STEDRONSKY, KATRIN</creatorcontrib><creatorcontrib>BUSCHMANN, THOMAS</creatorcontrib><creatorcontrib>FUCHS, MIRIAM</creatorcontrib><creatorcontrib>MEUER, JOERN</creatorcontrib><creatorcontrib>PEREZ, SILVIA TORTOLA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAMER, STEPHANIE</au><au>ROTHMANN-COSIC, KIRSTEN</au><au>SEIBERT, VOLKER</au><au>LEHNHERR-ILIANIA, TATIANA</au><au>FOTIADIS, NIKOLETA-KYRIAKI</au><au>HEIM, STEFFEN</au><au>STEDRONSKY, KATRIN</au><au>BUSCHMANN, THOMAS</au><au>FUCHS, MIRIAM</au><au>MEUER, JOERN</au><au>PEREZ, SILVIA TORTOLA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Differentially Expressed Tumour-specific Polypeptides for use in the Diagnosis and Treatment of Cancer</title><date>2009-09-02</date><risdate>2009</risdate><abstract>The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin-like protein (SYPL), stomatin-like 2 (STOML2), Ras-related GTP-binding protein RAGA), nucleotide-sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE |
| title | Differentially Expressed Tumour-specific Polypeptides for use in the Diagnosis and Treatment of Cancer |
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