BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE
The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R 1 represents...
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| creator | OGATA, TSUNEAKI OHSUMI, JUN ABE, MANABU HONDA, TAKESHI IZUMI, MASANORI OKUYAMA, RYO YOSHIDA, MASAO OGUCHI, MINORU UEDA, KENJIRO |
| description | The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I):
wherein
R 1 represents a hydrogen atom, an amino group, a hydroxy C 1 -C 6 alkyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a C 1 -C 6 alkyl group, a hydroxy C 1 -C 6 alkyl group, etc.; R 4 represents a hydrogen atom, a C 2 -C 7 acyl group, etc.; R 5 , R 6 , R 7 , and R 8 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl group, provided that R 5 , R 6 , R 7 and R 8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N. |
| format | Patent |
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wherein
R 1 represents a hydrogen atom, an amino group, a hydroxy C 1 -C 6 alkyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a C 1 -C 6 alkyl group, a hydroxy C 1 -C 6 alkyl group, etc.; R 4 represents a hydrogen atom, a C 2 -C 7 acyl group, etc.; R 5 , R 6 , R 7 , and R 8 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl group, provided that R 5 , R 6 , R 7 and R 8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110629&DB=EPODOC&CC=EP&NR=2048150A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110629&DB=EPODOC&CC=EP&NR=2048150A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OGATA, TSUNEAKI</creatorcontrib><creatorcontrib>OHSUMI, JUN</creatorcontrib><creatorcontrib>ABE, MANABU</creatorcontrib><creatorcontrib>HONDA, TAKESHI</creatorcontrib><creatorcontrib>IZUMI, MASANORI</creatorcontrib><creatorcontrib>OKUYAMA, RYO</creatorcontrib><creatorcontrib>YOSHIDA, MASAO</creatorcontrib><creatorcontrib>OGUCHI, MINORU</creatorcontrib><creatorcontrib>UEDA, KENJIRO</creatorcontrib><title>BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE</title><description>The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I):
wherein
R 1 represents a hydrogen atom, an amino group, a hydroxy C 1 -C 6 alkyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a C 1 -C 6 alkyl group, a hydroxy C 1 -C 6 alkyl group, etc.; R 4 represents a hydrogen atom, a C 2 -C 7 acyl group, etc.; R 5 , R 6 , R 7 , and R 8 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl group, provided that R 5 , R 6 , R 7 and R 8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBwcvWLivRRCPBw9QNS7j6hzv4BkUGOfv7Bni6uCi6uQZ5hjiGeYa48DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeNcDIwMTC0NTA0cSYCCUA7skkFA</recordid><startdate>20110629</startdate><enddate>20110629</enddate><creator>OGATA, TSUNEAKI</creator><creator>OHSUMI, JUN</creator><creator>ABE, MANABU</creator><creator>HONDA, TAKESHI</creator><creator>IZUMI, MASANORI</creator><creator>OKUYAMA, RYO</creator><creator>YOSHIDA, MASAO</creator><creator>OGUCHI, MINORU</creator><creator>UEDA, KENJIRO</creator><scope>EVB</scope></search><sort><creationdate>20110629</creationdate><title>BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE</title><author>OGATA, TSUNEAKI ; OHSUMI, JUN ; ABE, MANABU ; HONDA, TAKESHI ; IZUMI, MASANORI ; OKUYAMA, RYO ; YOSHIDA, MASAO ; OGUCHI, MINORU ; UEDA, KENJIRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2048150A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>OGATA, TSUNEAKI</creatorcontrib><creatorcontrib>OHSUMI, JUN</creatorcontrib><creatorcontrib>ABE, MANABU</creatorcontrib><creatorcontrib>HONDA, TAKESHI</creatorcontrib><creatorcontrib>IZUMI, MASANORI</creatorcontrib><creatorcontrib>OKUYAMA, RYO</creatorcontrib><creatorcontrib>YOSHIDA, MASAO</creatorcontrib><creatorcontrib>OGUCHI, MINORU</creatorcontrib><creatorcontrib>UEDA, KENJIRO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OGATA, TSUNEAKI</au><au>OHSUMI, JUN</au><au>ABE, MANABU</au><au>HONDA, TAKESHI</au><au>IZUMI, MASANORI</au><au>OKUYAMA, RYO</au><au>YOSHIDA, MASAO</au><au>OGUCHI, MINORU</au><au>UEDA, KENJIRO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE</title><date>2011-06-29</date><risdate>2011</risdate><abstract>The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I):
wherein
R 1 represents a hydrogen atom, an amino group, a hydroxy C 1 -C 6 alkyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a C 1 -C 6 alkyl group, a hydroxy C 1 -C 6 alkyl group, etc.; R 4 represents a hydrogen atom, a C 2 -C 7 acyl group, etc.; R 5 , R 6 , R 7 , and R 8 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl group, provided that R 5 , R 6 , R 7 and R 8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE |
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