SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
The invention relates to substituted arylpyrazolopyridines according to the general formula (1) : in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods...
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| creator | LIENAU, PHILIP THIERAUCH, KARL-HEINZ INCE, STUART TER LAAK, ANTONIUS M HARTUNG, INGO KETTSCHAU, GEORG BRIEM, HANS |
| description | The invention relates to substituted arylpyrazolopyridines according to the general formula (1) :
in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling. |
| format | Patent |
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in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090311&DB=EPODOC&CC=EP&NR=2032573A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090311&DB=EPODOC&CC=EP&NR=2032573A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIENAU, PHILIP</creatorcontrib><creatorcontrib>THIERAUCH, KARL-HEINZ</creatorcontrib><creatorcontrib>INCE, STUART</creatorcontrib><creatorcontrib>TER LAAK, ANTONIUS M</creatorcontrib><creatorcontrib>HARTUNG, INGO</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>BRIEM, HANS</creatorcontrib><title>SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME</title><description>The invention relates to substituted arylpyrazolopyridines according to the general formula (1) :
in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwkAQRNNYiPoP-wER1CDWa7LxDnK543aviE0IclaigfgZfrQxaG81zLyZmScvDkcWLUGoAPRN5RqPZ1vZUXWha2LAugDGShhEkSdbpuAUeoM5BdE5VpBb4yxr0bbmyXjNuj6NK0MpGBJlCwZbgvPk0P_Q9ByYJvQJlsns2t2GuPrqIoGSJFfr2D_aOPTdJd7jsyW322S7_SHDbfZH5Q13RD-l</recordid><startdate>20090311</startdate><enddate>20090311</enddate><creator>LIENAU, PHILIP</creator><creator>THIERAUCH, KARL-HEINZ</creator><creator>INCE, STUART</creator><creator>TER LAAK, ANTONIUS M</creator><creator>HARTUNG, INGO</creator><creator>KETTSCHAU, GEORG</creator><creator>BRIEM, HANS</creator><scope>EVB</scope></search><sort><creationdate>20090311</creationdate><title>SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME</title><author>LIENAU, PHILIP ; THIERAUCH, KARL-HEINZ ; INCE, STUART ; TER LAAK, ANTONIUS M ; HARTUNG, INGO ; KETTSCHAU, GEORG ; BRIEM, HANS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2032573A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2009</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIENAU, PHILIP</creatorcontrib><creatorcontrib>THIERAUCH, KARL-HEINZ</creatorcontrib><creatorcontrib>INCE, STUART</creatorcontrib><creatorcontrib>TER LAAK, ANTONIUS M</creatorcontrib><creatorcontrib>HARTUNG, INGO</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>BRIEM, HANS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIENAU, PHILIP</au><au>THIERAUCH, KARL-HEINZ</au><au>INCE, STUART</au><au>TER LAAK, ANTONIUS M</au><au>HARTUNG, INGO</au><au>KETTSCHAU, GEORG</au><au>BRIEM, HANS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME</title><date>2009-03-11</date><risdate>2009</risdate><abstract>The invention relates to substituted arylpyrazolopyridines according to the general formula (1) :
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME |
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