IMPROVEMENTS IN THERAPY FOR TREATING RESISTANT BACTERIAL INFECTIONS

IMPROVEMENTS IN THERAPY FOR TREATING RESISTANT BACTERIAL INFECTIONS

The invention relates to an improved therapy for treating resistant bacterial infections caused by extended-spectrum beta-lactamase (ESBLs)-producing strains in a warm-blooded animal, adjuvant step down therapy, and pharmaceutical compositions for such therapies. The invention also relates to a meth...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JAIN, GIRISH, KUMAR, PATEL, MAHESH, VITHALBHAI, JAFRI, MOHAMMAD, ALAM, KODGULE, MANDAR, MADHUKAR, BHAGWAT, SACHIN, SUBHASH, GUPTE, SHRIKANT, VINAYAK
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to an improved therapy for treating resistant bacterial infections caused by extended-spectrum beta-lactamase (ESBLs)-producing strains in a warm-blooded animal, adjuvant step down therapy, and pharmaceutical compositions for such therapies. The invention also relates to a method for inhibiting bacterial resistance in ESBLs-producing strains so as to have better control over the therapy; achieve reduced hospital stay and adjuvant step down therapy so as to avoid recrudescence. In particular, the therapy includes antibacterial combination of cefepime with sulbactam via parenteral route, followed by oral third generation cephalosporin with a suitable beta lactamase inhibitor.